Das Soumi, Dolai Jayanta, Roy Debiprasad, Maity Anupam, Jana Nikhil R
School of Materials Science, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Kolkata 700032, India.
ACS Appl Mater Interfaces. 2025 Jul 2;17(26):37539-37547. doi: 10.1021/acsami.5c05536. Epub 2025 Jun 16.
The aggregation of amyloid proteins is responsible for a range of neurodegenerative diseases, and disintegrating these fibrils in the brain is a critical aspect for therapy. Here, we show that an ultrasound-based sono-piezocatalytic approach can be adapted for the wireless disintegration of amyloid protein fibrils in remote areas. Piezoelectric barium titanate nanorods are designed for interaction with amyloid fibrils, and ultrasound is used for the sono-piezocatalytic generation of reactive oxygen species that disintegrate fibrils into smaller fragments via oxidative degradation. We found that superoxide radicals are primarily involved in the oxidative degradation of fibrils and convert β-sheet structures into random coil structures that are nontoxic in nature. This work shows the potential of piezoelectric nanomaterials for ultrasound-based therapy of neurodegenerative diseases.
淀粉样蛋白的聚集是一系列神经退行性疾病的病因，而在大脑中分解这些纤维是治疗的关键环节。在此，我们表明基于超声的声压电催化方法可用于远程区域淀粉样蛋白纤维的无线分解。设计了压电钛酸钡纳米棒以与淀粉样纤维相互作用，并利用超声通过声压电催化产生活性氧，这些活性氧通过氧化降解将纤维分解成更小的片段。我们发现超氧自由基主要参与纤维的氧化降解，并将β-折叠结构转化为本质上无毒的无规卷曲结构。这项工作展示了压电纳米材料在基于超声的神经退行性疾病治疗中的潜力。
