有丝分裂和减数分裂过程中Separase活性调控的细微差别。
Nuances in the control of separase activity between mitosis and meiosis.
作者信息
Anger Martin
机构信息
Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Libechov, Czech Republic.
Department of Genetics and Reproductive Biotechnologies, Veterinary Research Institute, Brno, Czech Republic.
出版信息
PLoS Biol. 2025 Jun 16;23(6):e3003206. doi: 10.1371/journal.pbio.3003206. eCollection 2025 Jun.
Abstract
Mammalian oocytes are prone to chromosome segregation errors, which frequently lead into aneuploidy and pregnancy loss. A new study in PLOS Biology addresses the role of the Mad2/SGO2 complex in the control of separase activity in these cells during meiosis.
摘要
哺乳动物的卵母细胞容易出现染色体分离错误，这常常导致非整倍体和妊娠丢失。发表在《公共科学图书馆·生物学》上的一项新研究探讨了Mad2/SGO2复合体在减数分裂期间对这些细胞中分离酶活性控制的作用。
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