• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Humanized mice to model rare human diseases.

作者信息

Suva Larry J

机构信息

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.

出版信息

Proc Natl Acad Sci U S A. 2025 Jun 24;122(25):e2512731122. doi: 10.1073/pnas.2512731122. Epub 2025 Jun 16.

DOI:10.1073/pnas.2512731122
PMID:40523196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12207434/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9889/12207434/d642ca95a9e4/pnas.2512731122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9889/12207434/d642ca95a9e4/pnas.2512731122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9889/12207434/d642ca95a9e4/pnas.2512731122fig01.jpg

相似文献

1
Humanized mice to model rare human diseases.用于模拟罕见人类疾病的人源化小鼠。
Proc Natl Acad Sci U S A. 2025 Jun 24;122(25):e2512731122. doi: 10.1073/pnas.2512731122. Epub 2025 Jun 16.
2
Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver.人源化肝脏嵌合小鼠中毛果芸香碱氧化和水解代谢的研究。
Drug Metab Pharmacokinet. 2025 Jun;62:101484. doi: 10.1016/j.dmpk.2025.101484. Epub 2025 Apr 14.
3
Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs.将有机阴离子转运多肽（OATP）1B1和OATP1B3人源化大鼠作为研究OATP1B底物药物药代动力学的转化模型进行表征。
Drug Metab Dispos. 2025 Jun 2;53(7):100101. doi: 10.1016/j.dmd.2025.100101.
4
Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma.在人源化小鼠中生成原位患者来源的异种移植瘤，用于评估黑色素瘤新兴靶向治疗和免疫治疗联合方案
Cancers (Basel). 2023 Jul 20;15(14):3695. doi: 10.3390/cancers15143695.
5
Exploring the immune environment of glioblastoma through single-cell RNA sequencing in humanized mouse models.通过人源化小鼠模型中的单细胞RNA测序探索胶质母细胞瘤的免疫环境。
bioRxiv. 2025 May 22:2025.05.17.654526. doi: 10.1101/2025.05.17.654526.
6
Humanized Mice as Unique Tools for Human-Specific Studies.人源化小鼠作为用于人类特异性研究的独特工具。
Arch Immunol Ther Exp (Warsz). 2018 Aug;66(4):245-266. doi: 10.1007/s00005-018-0506-x. Epub 2018 Feb 7.
7
Establishment of a human microbiome- and immune system-reconstituted dual-humanized mouse model.建立人类微生物组和免疫系统重建的双重人源化小鼠模型。
Exp Anim. 2023 Aug 7;72(3):402-412. doi: 10.1538/expanim.23-0025. Epub 2023 Apr 4.
8
Humanized mice in infectious diseases.传染病中的人源化小鼠
Comp Immunol Microbiol Infect Dis. 2016 Dec;49:29-38. doi: 10.1016/j.cimid.2016.08.006. Epub 2016 Aug 21.
9
Liver-humanized mice: A translational strategy to study metabolic disorders.肝人源化小鼠：一种用于研究代谢紊乱的转化策略。
J Cell Physiol. 2022 Jan;237(1):489-506. doi: 10.1002/jcp.30610. Epub 2021 Oct 18.
10
Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment.用于透明细胞肾细胞癌治疗的生物靶向双重适应性和先天性纳米免疫疗法。
Mol Cancer. 2025 Jun 18;24(1):181. doi: 10.1186/s12943-025-02382-y.

本文引用的文献

1
A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.用于研究疾病机制和候选治疗方法的詹森干骺端软骨发育不良小鼠模型。
Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2500176122. doi: 10.1073/pnas.2500176122. Epub 2025 Jun 2.
2
Substantially Delayed Maturation of Growth Plate Chondrocytes in "Humanized" Mice with the H223R Mutation of Jansen's Disease.患有詹森氏病H223R突变的“人源化”小鼠生长板软骨细胞成熟显著延迟。
JBMR Plus. 2023 Aug 15;7(10):e10802. doi: 10.1002/jbm4.10802. eCollection 2023 Oct.
3
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice.
人源化 PTH1R 敲入小鼠中甲状旁腺激素配体类似物的作用。
Endocrinology. 2022 Jul 1;163(7). doi: 10.1210/endocr/bqac054.
4
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate.甲状旁腺激素相关蛋白靶向盐诱导激酶、HDAC4 和 HDAC5，抑制生长板中的软骨细胞肥大。
Bone. 2021 Jan;142:115709. doi: 10.1016/j.bone.2020.115709. Epub 2020 Oct 24.
5
Engineering bone phenotypes in domestic animals: Unique resources for enhancing musculoskeletal research.在家畜中构建骨表型：增强肌肉骨骼研究的独特资源。
Bone. 2020 Jan;130:115119. doi: 10.1016/j.bone.2019.115119. Epub 2019 Nov 8.
6
An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia.甲状旁腺激素受体的反向激动剂配体可部分挽救詹森干骺端软骨发育不良小鼠模型中的骨骼缺陷。
J Bone Miner Res. 2020 Mar;35(3):540-549. doi: 10.1002/jbmr.3913. Epub 2019 Dec 4.
7
Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutations With or Without Overt Hypercalcemia.因杂合性H223R-PTH1R突变导致的詹森干骺端软骨发育不良，伴或不伴明显高钙血症。
J Clin Endocrinol Metab. 2016 Nov;101(11):4283-4289. doi: 10.1210/jc.2016-2054. Epub 2016 Jul 13.
8
Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.通过詹森转基因的靶向表达部分挽救甲状旁腺激素/甲状旁腺激素相关蛋白受体基因敲除小鼠。
Endocrinology. 2001 Dec;142(12):5303-10. doi: 10.1210/endo.142.12.8553.
9
Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.甲状旁腺激素（PTH）/PTH相关肽受体在詹森干骺端软骨发育不良的两个位点发生突变，导致环磷酸腺苷信号通路的组成性激活。
Mol Endocrinol. 1997 Jun;11(7):851-8. doi: 10.1210/mend.11.7.9934.
10
A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.詹森型干骺端软骨发育不良中一种组成型激活的突变型甲状旁腺激素-甲状旁腺激素相关蛋白受体
Science. 1995 Apr 7;268(5207):98-100. doi: 10.1126/science.7701349.