Ernst W
Clinic of Gynecology and Obstetrics St. Hedwig, University of Regensburg, Regensburg, Bavaria, Germany.
Comp Immunol Microbiol Infect Dis. 2016 Dec;49:29-38. doi: 10.1016/j.cimid.2016.08.006. Epub 2016 Aug 21.
The pathogenesis of infectious agents with human tropism can only be properly studied in an in vivo model featuring human cells or tissue. Humanized mice represent a small animal model featuring human cells or tissue that can be infected by human-specific viruses, bacteria, and parasites and also providing a functional human immune system. This makes the analysis of a human immune response to infection possible and allows for preclinical testing of new vaccines and therapeutic agents. Results of various studies using humanized mice to investigate pathogens with human tropism are presented in this review. In addition, the limitations of humanized mice and methods to improve this valuable animal model are discussed.
具有人嗜性的感染因子的发病机制只能在以人细胞或组织为特征的体内模型中进行恰当研究。人源化小鼠是一种以人细胞或组织为特征的小动物模型，可被人类特异性病毒、细菌和寄生虫感染，并且还具备功能性的人类免疫系统。这使得分析人类对感染的免疫反应成为可能，并允许对新疫苗和治疗药物进行临床前测试。本综述介绍了使用人源化小鼠研究具有人嗜性的病原体的各种研究结果。此外，还讨论了人源化小鼠的局限性以及改进这一有价值动物模型的方法。
