Shaoyong Lin, Huang Huanxiang, Wang Mingyue, Li Jun, Chen Yuhui, Wang Shousen
Department of Neurosurgery, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
Department of Neurosurgery, Dongfang Hospital of Xiamen University, Fuzhou, Fujian, China.
J Neurosurg Case Lessons. 2025 Jun 16;9(24). doi: 10.3171/CASE24765.
Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs).
The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy.
Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients. Combined therapeutic strategies may be considered for radiation-induced sarcomas, and comprehensive molecular pathological studies of radiation-induced tumors are imperative for advancing understanding and management. https://thejns.org/doi/10.3171/CASE24765.
癌肉瘤转化是垂体腺瘤（PAs）放疗后一种罕见的并发症。
作者报告了他们认为是首例良性无功能垂体腺瘤在手术和放疗后发展为癌肉瘤的病例。
垂体腺瘤放疗应考虑继发颅内肿瘤的风险，建议对接受治疗的患者进行长期随访。对于辐射诱导的肉瘤可考虑联合治疗策略，对辐射诱导的肿瘤进行全面的分子病理学研究对于增进认识和管理至关重要。https://thejns.org/doi/10.3171/CASE24765 。
