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一种酷似神经鞘瘤的疾病:马尾神经孤立性纤维瘤。病例说明

A schwannoma look-alike: solitary fibrous tumor of the cauda equina. Illustrative case.

作者信息

Fischer Marc, Harnisch Kim, Rushing Elisabeth, Fandino Javier, Saemann Attill

机构信息

Department of Neurosurgery, Klinik Hirslanden Aarau/Zürich, Switzerland.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland.

出版信息

J Neurosurg Case Lessons. 2025 Jun 16;9(24). doi: 10.3171/CASE2585.

Abstract

BACKGROUND

Solitary fibrous tumors (SFTs) and schwannomas are two types of spinal neoplasms that pose significant challenges in differentiation when utilizing the preferred diagnostic modality for suspected spinal lesions, MRI. While schwannomas are generally subject to observation, particularly when presenting with asymptomatic or oligosymptomatic manifestation. SFTs require more immediate therapeutic intervention, due to their potentially aggressive characteristics and associated risk of patient harm if they are not thoroughly resected and addressed early.

OBSERVATIONS

A 79-year-old patient was referred to the authors' clinic after receiving a diagnosis of schwannoma of the cauda equina 3 years earlier. Because of the oligosymptomatic presentation, the attending physician then implemented a watch-and-wait approach. A gross-total resection (GTR) was undertaken following progressive enlargement observed on successive MR images. The definitive pathological diagnosis revealed a grade 1 SFT.

LESSONS

Spinal SFT should be regarded as a potentially aggressive neoplasm characterized by an invasive propensity toward adjacent structures as well as distal metastases. The adoption of conservative management for ambiguous lesions may increase the risk of an adverse outcome. Therefore, in the context of uncertain spinal lesions with inconclusive MRI findings, it may be advisable to proceed with GTR in conjunction with confirmation of the definitive pathological diagnosis. https://thejns.org/doi/10.3171/CASE2585.

摘要

背景

孤立性纤维瘤(SFTs)和神经鞘瘤是两种脊柱肿瘤,在使用疑似脊柱病变的首选诊断方式——磁共振成像(MRI)进行鉴别时面临重大挑战。虽然神经鞘瘤通常只需观察,尤其是在出现无症状或症状轻微的表现时。但SFTs因其潜在的侵袭性特征以及若不早期彻底切除和处理会给患者带来伤害的风险,需要更及时的治疗干预。

观察结果

一名79岁患者在3年前被诊断为马尾神经鞘瘤后转诊至作者所在诊所。由于症状轻微,主治医生采取了观察等待的方法。在连续的磁共振图像上观察到肿瘤逐渐增大后进行了全切除(GTR)。最终病理诊断显示为1级SFT。

经验教训

脊柱SFT应被视为一种潜在侵袭性肿瘤,其特征是倾向于侵犯相邻结构以及发生远处转移。对不明确的病变采用保守治疗可能会增加不良后果的风险。因此,在MRI检查结果不明确的脊柱病变情况下,结合明确的病理诊断进行GTR手术可能是可取的。https://thejns.org/doi/10.3171/CASE2585

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