Tsukamoto Yutaka, Umeda Masataka, Sugimoto Takashi, Matsuoka Yuki, Kato Takeharu, Nakashima Masahiro, Ariyoshi Koya, Maeda Takahiro
Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, JPN.
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.
Cureus. 2025 May 16;17(5):e84243. doi: 10.7759/cureus.84243. eCollection 2025 May.
Disseminated intravascular coagulation (DIC) is a systemic intravascular activation of coagulation caused by various underlying conditions. Severe DIC cases could be fatal. We present a 78-year-old Japanese man who developed uncontrollable DIC, finally diagnosed as lung cancer and intravascular invasion along the endothelium of the pulmonary artery, massive pulmonary embolism, and tumor embolism in autopsy. Leucocytes, platelets, and cancer cells play roles in uncontrollable DIC by assisting the attachment of cancer cells to endothelia. Endothelium damage enhances coagulation and suppresses fibrinolysis. This is the first case of uncontrollable DIC caused by intravascular invasion of lung cancer along the endothelium.
弥散性血管内凝血（DIC）是由各种潜在疾病引起的全身性血管内凝血激活。严重的DIC病例可能致命。我们报告一名78岁的日本男性，他发生了无法控制的DIC，最终在尸检中被诊断为肺癌并沿肺动脉内皮发生血管内侵犯、大面积肺栓塞和肿瘤栓塞。白细胞、血小板和癌细胞通过协助癌细胞附着于内皮而在无法控制的DIC中发挥作用。内皮损伤会增强凝血并抑制纤维蛋白溶解。这是首例由肺癌沿内皮血管内侵犯引起的无法控制的DIC病例。
