Ul Hassan Muhammad Saad, Mobusher Mariam, Mansoor Muhammad Hadi, Ahmad Chaudhary Adeel, Ahsan Iftikhar, Hamza Muhammad, Rasikh Muhammad, Qammar Bilal
General Surgery, DHQ Teaching Hospital, Gujranwala, Gujranwala, PAK.
General Surgery, Shalamar Hospital, Lahore, PAK.
Cureus. 2025 May 16;17(5):e84220. doi: 10.7759/cureus.84220. eCollection 2025 May.
Acute pancreatitis (AP) is a common and potentially life-threatening condition, with gallstones being a major etiology.
This study aims to determine how common AP is among patients with gallstones and to identify the associated risk factors, diagnostic laboratory markers, and potential complications.
This cross-sectional study was conducted at Shalamar Hospital, Lahore, a tertiary care center, from June 2024 to January 2025. Data were collected from 165 patients presenting in the Department of Gastroenterology and General Surgery. Patients were included if they had gallstones confirmed by abdominal ultrasound and met the revised Atlanta criteria for AP, including clinical symptoms (e.g., epigastric pain, nausea) and laboratory findings (serum lipase/amylase ≥3× upper limit of normal).
The prevalence of AP in patients with gallstones was 37.6% (62/165). Risk factors such as obesity (72%, 45/62), age (≥50 years, 72%, 45/62), and female gender (65%, 40/62) were significantly associated with the condition. Elevated serum amylase (225.4 ± 112.3 U/L) and lipase (317.8 ± 150.7 U/L), along with increased white blood cell (WBC) count (13.2 ± 4.6 x 10/L), C-reactive protein (CRP) (45.7 ± 19.2 mg/L), and bilirubin levels (2.4 ± 1.6 mg/dL), were observed, particularly in severe cases of AP. Pancreatic necrosis occurred in 13% (8/62), organ failure in 8% (5/62), and systemic inflammatory response syndrome (SIRS) in 16% (10/62). Cholecystectomy was performed in 69% (43/62) of cases, and the mortality rate was 3.2% (2/62).
Gallstones are a major cause of AP, with obesity, age, and female gender being key risk factors. Elevated laboratory markers correlate with the severity of the condition and can aid in disease assessment.
急性胰腺炎（AP）是一种常见且可能危及生命的疾病，胆结石是主要病因。
本研究旨在确定胆结石患者中AP的常见程度，并识别相关危险因素、诊断实验室指标及潜在并发症。
本横断面研究于2024年6月至2025年1月在拉合尔沙勒马尔医院（一家三级医疗中心）进行。从胃肠病学和普通外科就诊的165例患者中收集数据。若患者经腹部超声确诊有胆结石且符合修订后的AP亚特兰大标准，包括临床症状（如中上腹疼痛、恶心）和实验室检查结果（血清脂肪酶/淀粉酶≥3倍正常上限），则纳入研究。
胆结石患者中AP的患病率为37.6%（62/165）。肥胖（72%，45/62）、年龄（≥50岁，72%，45/62）和女性（65%，40/62）等危险因素与该病显著相关。观察到血清淀粉酶（225.4±112.3 U/L）和脂肪酶（317.8±150.7 U/L）升高，同时白细胞（WBC）计数（13.2±4.6×10/L）、C反应蛋白（CRP）（45.7±19.2 mg/L）和胆红素水平（2.4±1.6 mg/dL）也升高，尤其是在AP重症患者中。13%（8/62）发生胰腺坏死，8%（5/62）发生器官衰竭，16%（10/62）发生全身炎症反应综合征（SIRS）。69%（43/62）的病例进行了胆囊切除术，死亡率为3.2%（2/62）。
胆结石是AP的主要病因，肥胖、年龄和女性是关键危险因素。实验室指标升高与病情严重程度相关，有助于疾病评估。
