急性胰腺炎的临床特征、病因和转归：三级医疗中心的经验。
Clinical profile, etiology, and outcome of acute pancreatitis: Experience at a tertiary care center.
机构信息
Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Geriatric Mental Health, King George's Medical University, Lucknow, Uttar Pradesh, India.
出版信息
Ann Afr Med. 2022 Apr-Jun;21(2):118-123. doi: 10.4103/aam.aam_83_20.
BACKGROUND
Acute pancreatitis (AP) is an inflammatory process of the pancreas with varying degree of involvement of regional tissues. This was a population-based study on the incidence of AP. We aimed to determine the incidence, etiology, and outcome of AP.
MATERIALS AND METHODOLOGY
This prospective study was conducted in the Department of Medicine, King George's Medical University, Lucknow, India, on 120 patients of AP. Clinical history, examination, and laboratory investigations were done. Severity of AP was assessed using the modified Atlanta classification.
RESULTS
A total of 120 patients comprising of 88 men (73.33%) and 32 women (26.66%) were recruited. The mean age of study participant was 36.96 ± 13.44 years. The most common presentation was abdominal pain followed by vomiting. The leading etiological factors were alcohol in 85 patients (70.8%) and gallstones in 25 (20.8%). It was idiopathic 5 patients (4.1%). Mortality was seen in three (2.5%) patients, all of which had severe pancreatitis. Patients with body mass index (BMI) ≥25 kg/m, Hematocrit (HCT) ≥44% and C-reactive protein (CRP) ≥150 mg/l had an increased risk of developing a severe AP.
CONCLUSIONS
Alcohol and gallstones were the most common etiological factors of AP, whereas HCT, CRP, and BMI were the useful predictors of severe pancreatitis.
背景
急性胰腺炎（AP）是一种胰腺的炎症过程，伴有不同程度的局部组织受累。这是一项基于人群的 AP 发病率研究。我们旨在确定 AP 的发病率、病因和结局。
材料和方法
这项前瞻性研究在印度勒克瑙的乔治国王医学大学内科进行，共纳入了 120 例 AP 患者。进行了临床病史、检查和实验室检查。使用改良亚特兰大分类法评估 AP 的严重程度。
结果
共纳入了 120 例患者，包括 88 名男性（73.33%）和 32 名女性（26.66%）。研究参与者的平均年龄为 36.96 ± 13.44 岁。最常见的表现是腹痛，其次是呕吐。主要的病因因素是酒精 85 例（70.8%）和胆结石 25 例（20.8%）。5 例（4.1%）为特发性。有 3 例（2.5%）患者死亡，均为重症胰腺炎。BMI≥25kg/m、HCT≥44%和 CRP≥150mg/l 的患者发生重症 AP 的风险增加。
结论
酒精和胆结石是 AP 最常见的病因因素，而 HCT、CRP 和 BMI 是重症胰腺炎的有用预测指标。
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