Keles Muserrefe Nur, Ertoy Karagol Hacer Ilbilge, Yildiz Ramazan, Egritas Gurkan Odul, Sari Sinan, Elbasan Bulent, Dalgic Buket, Bakirtas Arzu
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Gazi University, Ankara, Turkey.
Faculty of Medicine, Department of Pediatric Allergy, Gazi University, Ankara, Turkey.
Brain Behav. 2025 Jun;15(6):e70642. doi: 10.1002/brb3.70642.
Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease associated with dysphagia, food impaction, feeding difficulties, vomiting, and failure to thrive in children. These symptoms result from dysregulated neural control and inflammation-induced tissue remodeling and may extend beyond esophageal dysfunction to impact sensory processing. This study aimed to evaluate the sensory processing difficulties in children with EoE.
This prospective case-control study included children with EoE and age-matched healthy controls. Sociodemographic data and medical histories were collected. Sensory processing abilities were evaluated using the sensory profile, which evaluates sensory performance across multiple domains.
A total of 69 children aged 3-10 years participated in the study, including 22 diagnosed with EoE and 47 healthy controls. No significant demographic differences were found between groups (p > 0.05). Children with EoE exhibited significantly greater sensory processing difficulties in oral sensory processing, vestibular processing, and oral sensory sensitivity compared to healthy controls (p < 0.001).
Sensory processing difficulties in children with EoE extend beyond feeding challenges, affecting oral sensory and vestibular processing functions. Incorporating sensory processing assessments into clinical evaluations may improve the understanding of sensory-related challenges in this population. A multidisciplinary approach could help refine clinical management strategies.
嗜酸性粒细胞性食管炎（EoE）是一种慢性炎症性食管疾病，与吞咽困难、食物嵌塞、喂养困难、呕吐以及儿童生长发育迟缓有关。这些症状是由神经控制失调和炎症诱导的组织重塑引起的，可能超出食管功能障碍的范围，影响感觉处理。本研究旨在评估EoE患儿的感觉处理困难情况。
这项前瞻性病例对照研究纳入了EoE患儿和年龄匹配的健康对照。收集了社会人口统计学数据和病史。使用感觉概况评估感觉处理能力，该评估在多个领域评估感觉表现。
共有69名3至10岁的儿童参与了研究，其中22名被诊断为EoE，47名是健康对照。两组之间在人口统计学上没有显著差异（p>0.05）。与健康对照相比，EoE患儿在口腔感觉处理、前庭处理和口腔感觉敏感性方面表现出明显更大的感觉处理困难（p<0.001）。
EoE患儿的感觉处理困难不仅限于喂养挑战，还影响口腔感觉和前庭处理功能。将感觉处理评估纳入临床评估可能会改善对该人群中与感觉相关挑战的理解。多学科方法有助于完善临床管理策略。
