Aiba S, Minoura N, Fujiwara Y, Yamada S, Nakagawa T
Biomaterials. 1985 Sep;6(5):290-6. doi: 10.1016/0142-9612(85)90084-5.
Laminates of synthetic polypeptides and elastomers, have been prepared, characterized and evaluated in terms of their application as a burn wound covering. It was found that the oxidation of L-methionine(Met)-containing polypeptide films by hydrogen peroxide led to an increase in the water vapour transmission rates (WVTR's) of the films. Elastomeric films had high WVTR's and good tensile properties for wound covering. The laminates composed of oxidized Met-containing copolypeptides and polyurethane had high WVTR's (790-1050 g X m-2 X day-1): for example, the laminate composed of an oxidized Met and N epsilon-benzyloxycarbonyl-L-lysine containing copolypeptide and polyurethane had high WVTR (960 g X m- X d-1) and large elongation (556%), also the cohesion between the two layers of this laminate was strong even after autoclaving. These characteristics seem to be very attractive for the possible application of laminates to wound covering. In addition the method of measuring WVTR is discussed.
已经制备了合成多肽和弹性体的层压材料，并对其作为烧伤创面覆盖物的应用进行了表征和评估。发现含L-甲硫氨酸（Met）的多肽膜被过氧化氢氧化会导致膜的水蒸气透过率（WVTR）增加。弹性体膜具有高WVTR和良好的拉伸性能，适合用于伤口覆盖。由氧化的含Met的共聚多肽和聚氨酯组成的层压材料具有高WVTR（790 - 1050 g×m-2×天-1）：例如，由氧化的Met和含Nε-苄氧羰基-L-赖氨酸的共聚多肽与聚氨酯组成的层压材料具有高WVTR（960 g×m-×d-1）和大伸长率（556%），而且即使在高压灭菌后，该层压材料两层之间的内聚力也很强。这些特性对于层压材料在伤口覆盖方面的可能应用似乎非常有吸引力。此外，还讨论了测量WVTR的方法。
