• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利妥昔单抗、保妥适和阿柏西普的扩散特性及其对肌肉松弛的影响：一项随机半脸临床试验。

Diffusion Characteristics of LetibotulinumtoxinA, OnabotulinumtoxinA, and AbobotulinumtoxinA and its Impact on Muscle Relaxation: A Randomized Split-Face Clinical Trial.

作者信息

Bennek Maxine, Rudowitz Daniela, Kerscher Martina

机构信息

Division of Cosmetic Science, Institute of Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther King Platz 6, 20146, Hamburg, Germany.

Croma-Pharma GmbH, Leobendorf, Austria.

出版信息

Dermatol Ther (Heidelb). 2025 Aug;15(8):2147-2158. doi: 10.1007/s13555-025-01458-3. Epub 2025 Jun 17.

DOI:10.1007/s13555-025-01458-3
PMID:40526262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12256374/
Abstract

INTRODUCTION

Injections with botulinumtoxinA (BoNTA) are the most common nonsurgical aesthetic procedure but carry risks such as unintended muscle diffusion. Understanding formulation behavior is key to optimizing safety and efficacy. This study compares the diffusion characteristics from letibotulinumtoxinA (Leti-BoNTA) to onabotulinumtoxinA (Ona-BoNTA) and abobotulinumtoxinA (Abo-BoNTA) and its impact on muscle relaxation of frontalis muscle.

METHODS

In a double-blind, randomized trial, 30 healthy adults received Leti-BoNTA on one forehead side and either Ona-BoNTA or Abo-BoNTA on the other. Anhidrosis was measured via Minor's starch test over 6 months, and wrinkle severity was assessed using standardized photography and the Croma Scale.

RESULTS

Leti-BoNTA had a significantly smaller maximal anhidrotic area than Ona-BoNTA (-15.1 ± 5.5 cm, p < 0.001) and Abo-BoNTA (-25.2 ± 14.5 cm, p < 0.001). An area under the curve (AUC) analysis confirmed the largest area of anhidrosis for Abo-BONTA over the 6-month period, followed by Ona-BONTA and Leti-BoNTA. Despite its lower diffusion, Leti-BoNTA effectively improved wrinkles, with ≥ 1-point improvement in 92% of subjects by week 2.

CONCLUSIONS

Leti-BoNTA provides wrinkle reduction with a more limited diffusion, as assessed with the Minor's starch-iodine test. Its precise action in this trial implies to be a viable option when controlled spread is essential.

CLINICAL TRIAL REGISTRATION

The trial EU CT: 2024-511047-26-01 was registered on 23 March 2024.

摘要

引言

注射A型肉毒杆菌毒素（BoNTA）是最常见的非手术美容方法，但存在诸如意外肌肉扩散等风险。了解制剂行为是优化安全性和有效性的关键。本研究比较了乐提葆A型肉毒毒素（Leti-BoNTA）与保妥适A型肉毒毒素（Ona-BoNTA）和衡力A型肉毒毒素（Abo-BoNTA）的扩散特性及其对额肌肌肉松弛的影响。

方法

在一项双盲随机试验中，30名健康成年人一侧额头注射乐提葆A型肉毒毒素，另一侧额头注射保妥适A型肉毒毒素或衡力A型肉毒毒素。通过Minor淀粉试验在6个月内测量无汗情况，并使用标准化摄影和色度量表评估皱纹严重程度。

结果

乐提葆A型肉毒毒素的最大无汗面积显著小于保妥适A型肉毒毒素（-15.1±5.5平方厘米，p<0.001）和衡力A型肉毒毒素（-25.2±14.5平方厘米，p<0.001）。曲线下面积（AUC）分析证实，在6个月期间，衡力A型肉毒毒素的无汗面积最大，其次是保妥适A型肉毒毒素和乐提葆A型肉毒毒素。尽管乐提葆A型肉毒毒素的扩散较小，但它能有效改善皱纹，到第2周时，92%的受试者皱纹改善≥1分。

结论

根据Minor淀粉碘试验评估，乐提葆A型肉毒毒素在扩散更有限的情况下实现了皱纹减少。在需要控制扩散的情况下，其在本试验中的精确作用意味着它是一个可行的选择。

临床试验注册

该试验EU CT: 2024-511047-26-01于2024年3月23日注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/bda3ded9b7ce/13555_2025_1458_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/075fceb1d618/13555_2025_1458_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/183160efdc71/13555_2025_1458_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/21cea4d112a1/13555_2025_1458_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/4427fb8e77d7/13555_2025_1458_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/a25051307647/13555_2025_1458_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/bda3ded9b7ce/13555_2025_1458_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/075fceb1d618/13555_2025_1458_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/183160efdc71/13555_2025_1458_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/21cea4d112a1/13555_2025_1458_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/4427fb8e77d7/13555_2025_1458_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/a25051307647/13555_2025_1458_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff0/12256374/bda3ded9b7ce/13555_2025_1458_Fig6_HTML.jpg

相似文献

1
Diffusion Characteristics of LetibotulinumtoxinA, OnabotulinumtoxinA, and AbobotulinumtoxinA and its Impact on Muscle Relaxation: A Randomized Split-Face Clinical Trial.利妥昔单抗、保妥适和阿柏西普的扩散特性及其对肌肉松弛的影响：一项随机半脸临床试验。
Dermatol Ther (Heidelb). 2025 Aug;15(8):2147-2158. doi: 10.1007/s13555-025-01458-3. Epub 2025 Jun 17.
2
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
3
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状荟萃分析。
Cochrane Database Syst Rev. 2017 Dec 22;12(12):CD011535. doi: 10.1002/14651858.CD011535.pub2.
4
Immunogenicity and seroefficacy of pneumococcal conjugate vaccines: a systematic review and network meta-analysis.肺炎球菌结合疫苗的免疫原性和血清效力：系统评价和网络荟萃分析。
Health Technol Assess. 2024 Jul;28(34):1-109. doi: 10.3310/YWHA3079.
5
A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer.对紫杉醇、多西他赛、吉西他滨和长春瑞滨在非小细胞肺癌中的临床疗效和成本效益进行的快速系统评价。
Health Technol Assess. 2001;5(32):1-195. doi: 10.3310/hta5320.
6
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病：网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
7
Home treatment for mental health problems: a systematic review.心理健康问题的居家治疗：一项系统综述
Health Technol Assess. 2001;5(15):1-139. doi: 10.3310/hta5150.
8
Comparison of Two Modern Survival Prediction Tools, SORG-MLA and METSSS, in Patients With Symptomatic Long-bone Metastases Who Underwent Local Treatment With Surgery Followed by Radiotherapy and With Radiotherapy Alone.两种现代生存预测工具 SORG-MLA 和 METSSS 在接受手术联合放疗和单纯放疗治疗有症状长骨转移患者中的比较。
Clin Orthop Relat Res. 2024 Dec 1;482(12):2193-2208. doi: 10.1097/CORR.0000000000003185. Epub 2024 Jul 23.
9
Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation.阿德福韦酯与聚乙二醇化干扰素α-2a治疗慢性乙型肝炎：系统评价与经济学评估
Health Technol Assess. 2006 Aug;10(28):iii-iv, xi-xiv, 1-183. doi: 10.3310/hta10280.
10
Falls prevention interventions for community-dwelling older adults: systematic review and meta-analysis of benefits, harms, and patient values and preferences.社区居住的老年人跌倒预防干预措施：系统评价和荟萃分析的益处、危害以及患者的价值观和偏好。
Syst Rev. 2024 Nov 26;13(1):289. doi: 10.1186/s13643-024-02681-3.

本文引用的文献

1
A Phase-III Noninferiority, Randomized Controlled Trial of Letibotulinum Toxin A for the Improvement of Moderate-to-Severe Glabellar Wrinkles in China.一项在中国进行的关于利替泊托菌素A改善中重度眉间皱纹的III期非劣效性随机对照试验。
Plast Reconstr Surg Glob Open. 2024 Jan 10;12(1):e5525. doi: 10.1097/GOX.0000000000005525. eCollection 2024 Jan.
2
Novel Validated Five-point Photonumeric Scales for Assessment of Static and Dynamic Forehead Lines.用于评估静态和动态额头纹的新型验证五点光子数字量表。
Plast Reconstr Surg Glob Open. 2023 Sep 21;11(9):e5287. doi: 10.1097/GOX.0000000000005287. eCollection 2023 Sep.
3
Efficacy and Safety of Letibotulinumtoxin A in the Treatment of Glabellar Lines: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Phase 3 Study.
利特肉毒毒素 A 治疗眉间纹的疗效和安全性：一项随机、双盲、多中心、安慰剂对照的 3 期研究。
Aesthet Surg J. 2022 May 18;42(6):677-688. doi: 10.1093/asj/sjac019.
4
The Bidirectional Movement of the Frontalis Muscle: Introducing the Line of Convergence and Its Potential Clinical Relevance.额肌的双向运动：介绍收敛线及其潜在的临床意义。
Plast Reconstr Surg. 2020 May;145(5):1155-1162. doi: 10.1097/PRS.0000000000006756.
5
Neurotoxin Impurities: A Review of Threats to Efficacy.神经毒素杂质：对疗效威胁的综述
Plast Reconstr Surg Glob Open. 2020 Jan 24;8(1):e2627. doi: 10.1097/GOX.0000000000002627. eCollection 2020 Jan.
6
OnabotulinumtoxinA and AbobotulinumtoxinA Dose Conversion: a Systematic Literature Review.A型肉毒毒素和阿柏型肉毒毒素的剂量转换：一项系统文献综述
Mov Disord Clin Pract. 2016 Mar-Apr;3(2):109-115. doi: 10.1002/mdc3.12235. Epub 2015 Oct 12.
7
Dysport and Botox at a ratio of 2.5:1 units in cervical dystonia: a double-blind, randomized study.肉毒杆菌素A与保妥适以2.5:1单位比例用于治疗颈部肌张力障碍：一项双盲随机研究
Mov Disord. 2015 Feb;30(2):206-13. doi: 10.1002/mds.26085. Epub 2014 Dec 5.
8
Botulinum toxin type A products are not interchangeable: a review of the evidence.A型肉毒毒素产品不可互换：证据综述
Biologics. 2014 Oct 6;8:227-41. doi: 10.2147/BTT.S65603. eCollection 2014.
9
Double-blind, randomized non-inferiority trial of a novel botulinum toxin A processed from the strain CBFC26, compared with onabotulinumtoxin A in the treatment of glabellar lines.一项关于从CBFC26菌株加工而来的新型A型肉毒杆菌毒素与A型肉毒毒素治疗眉间纹的双盲、随机非劣效性试验。
J Eur Acad Dermatol Venereol. 2014 Dec;28(12):1761-7. doi: 10.1111/jdv.12408. Epub 2014 Mar 5.
10
[Botulinum toxin in dermatology].[肉毒杆菌毒素在皮肤科的应用]
Hautarzt. 2014 Feb;65(2):133-43; quiz 144-5. doi: 10.1007/s00105-013-2744-5.