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Role of Galangin for the Treatment of Alzheimer's Disease: Journey So Far and Road Ahead.

作者信息

Sharma Prince, Sharma Tripti, Bashir Bushra, Andotra Nandani, Awasthi Ankit, Patel Priya, Subramaniyan Vetriselvan, Chellappan Dinesh Kumar, Gupta Gaurav, Vishwas Sukriti, Singh Sachin Kumar

机构信息

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.

出版信息

Curr Nutr Rep. 2025 Jun 17;14(1):80. doi: 10.1007/s13668-025-00669-6.

DOI:10.1007/s13668-025-00669-6
PMID:40526360
Abstract
摘要

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Role of Galangin for the Treatment of Alzheimer's Disease: Journey So Far and Road Ahead.高良姜在阿尔茨海默病治疗中的作用：既往历程与未来之路
Curr Nutr Rep. 2025 Jun 17;14(1):80. doi: 10.1007/s13668-025-00669-6.
2
Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment.姜黄素挽救阿尔茨海默病淀粉样β诱导的线粒体自噬和脑类器官生长障碍。
Int J Mol Sci. 2023 Feb 8;24(4):3398. doi: 10.3390/ijms24043398.
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Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells.高良姜素通过表观遗传机制诱导SH-SY5Y细胞中β-分泌酶1（BACE1）的表达下调。
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Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.超声传递 TrkA 激动剂可赋予阿尔茨海默病相关病理神经保护作用。
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Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism.姜黄素通过 Akt/GSK3β/mTOR 信号通路依赖性机制降低 okadaic 酸诱导的 PC12 细胞中的 p-tau、Aβ42 和 β-分泌酶水平，并抑制自噬。
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本文引用的文献

1
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.高良姜素通过自噬依赖的PI3K/AKT途径减轻MPTP诱导的多巴胺能神经元损伤。
Front Aging Neurosci. 2025 Apr 4;17:1568002. doi: 10.3389/fnagi.2025.1568002. eCollection 2025.
2
Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation.高良姜素的镇痛和抗炎作用：抑制瞬时受体电位香草酸亚型1受体激活的潜在途径。
Korean J Pain. 2024 Apr 1;37(2):151-163. doi: 10.3344/kjp.23363.
3
Recent advancement in therapeutic strategies for Alzheimer's disease: Insights from clinical trials.
阿尔茨海默病治疗策略的最新进展：来自临床试验的见解
Ageing Res Rev. 2023 Dec;92:102113. doi: 10.1016/j.arr.2023.102113. Epub 2023 Oct 31.
4
Pharmacological activities and therapeutic potential of galangin, a promising natural flavone, in age-related diseases.高良姜素（一种有前景的天然黄酮）在与年龄相关疾病中的药理活性及治疗潜力
Phytomedicine. 2023 Nov;120:155061. doi: 10.1016/j.phymed.2023.155061. Epub 2023 Sep 4.
5
Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment.姜黄素挽救阿尔茨海默病淀粉样β诱导的线粒体自噬和脑类器官生长障碍。
Int J Mol Sci. 2023 Feb 8;24(4):3398. doi: 10.3390/ijms24043398.
6
Hallmarks of neurodegenerative diseases.神经退行性疾病的特征。
Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032.
7
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint.草药治疗阿尔茨海默病：从现代角度看古印度医学体系。
Curr Neuropharmacol. 2023;21(4):764-776. doi: 10.2174/1570159X21666230216094353.
8
Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β.色氨酸代谢通路的系统性紊乱先于淀粉样蛋白-β进展为痴呆症。
Neurobiol Dis. 2022 Sep;171:105783. doi: 10.1016/j.nbd.2022.105783. Epub 2022 Jun 5.
9
Genetics of Alzheimer's disease.阿尔茨海默病的遗传学。
Wien Med Wochenschr. 2021 Sep;171(11-12):249-256. doi: 10.1007/s10354-021-00819-9. Epub 2021 Feb 22.
10
Galangin Inhibits LPS-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent AP-1 and FoxO1 Activation in Rat Brain Astrocytes.高良姜素通过抑制大鼠脑星形胶质细胞中蛋白激酶依赖性AP-1和FoxO1激活来抑制脂多糖诱导的MMP-9表达。
J Inflamm Res. 2020 Nov 20;13:945-960. doi: 10.2147/JIR.S276925. eCollection 2020.