Kilic F S, Kaygisiz B, Aydin S, Yildirim E, Oner S, Erol K
Bratisl Lek Listy. 2019;120(12):881-886. doi: 10.4149/BLL_2019_148.
Galangin, a flavonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission.
We aimed to investigate the effects of galangin on spatial memory impairment in rats.
The effects of galangin (50 and 100 mg/kg) and reference anti-dementia drug donepezil (1mg/kg) administrations were examined on memory impairment induced by the muscarinic cholinergic receptor antagonist scopolamine or the nicotinic cholinergic receptor antagonist mecamylamine in the Morris water maze (MWM) test. Hippocampal acetylcholine concentrations were also determined.
Galangin 50 and 100 mg/kg significantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in scopolamine-treated rats. Galangin 100 mg/kg significantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in mecamylamine-treated rats. The effects of galangin in the MWM were comparable with donepezil. Scopolamine and mecamylamine decreased acetylcholine concentrations, whereas galangin both alone and with mecamylamine or scopolamine administration increased acetylcholine concentrations.
Galangin improved memory impairment comparable to donepezil and nicotinic and muscarinic receptors may be involved in this effect. Galangin may be considered as a promising flavonoid in the prevention and treatment of memory impairment in Alzheimer's disease and other dementias (Fig. 7,Ref. 37).
高良姜素是一种具有乙酰胆碱酯酶抑制活性的黄酮类化合物，可能通过增强胆碱能传递来改善认知功能。
我们旨在研究高良姜素对大鼠空间记忆损伤的影响。
在莫里斯水迷宫（MWM）试验中，检测了高良姜素（50和100mg/kg）和参比抗痴呆药物多奈哌齐（1mg/kg）对由毒蕈碱型胆碱能受体拮抗剂东莨菪碱或烟碱型胆碱能受体拮抗剂美加明诱导的记忆损伤的作用。还测定了海马中的乙酰胆碱浓度。
50和100mg/kg的高良姜素显著缩短了东莨菪碱处理大鼠到达平台的平均距离，并增加了其在逃生平台象限的停留时间。100mg/kg的高良姜素显著缩短了美加明处理大鼠到达平台的平均距离，并增加了其在逃生平台象限的停留时间。高良姜素在MWM试验中的作用与多奈哌齐相当。东莨菪碱和美加明降低了乙酰胆碱浓度，而单独使用高良姜素以及与美加明或东莨菪碱联合使用时，高良姜素均增加了乙酰胆碱浓度。
高良姜素改善记忆损伤的效果与多奈哌齐相当，且烟碱型和毒蕈碱型受体可能参与了这一作用。高良姜素可能被认为是预防和治疗阿尔茨海默病及其他痴呆症记忆损伤的一种有前景的黄酮类化合物（图7，参考文献37）。
