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二十年来与疼痛管理相关的用药错误:澳大利亚非阿片类镇痛药、退烧药和抗风湿药的住院情况

Two decades of medication administration errors related to pain management: Hospital admissions for nonopioid analgesics, antipyretics, and antirheumatics in Australia.

作者信息

El-Qasem Asaleh, Naser Abdallah Y, Alsharif Alaa A

机构信息

Faculty of Pharmacy, University of Jordan, Amman, Jordan.

Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan.

出版信息

Medicine (Baltimore). 2025 Jun 13;104(24):e42893. doi: 10.1097/MD.0000000000042893.

Abstract

The rate of medication poisoning is constantly increasing globally, increasing the number of hospital admissions and the burden on the health system. In Australia, nonopioid analgesics, antipyretics, and antirheumatics medications cause a high rate of accidental poisonings. This study aims to study hospital admissions trends related to medication administration errors (MAEs; poisoning by, adverse effect of and underdosing of) of nonopioid analgesics, antipyretics, and antirheumatics-related in Australia from 1998 to 2022. This ecological study used hospital admissions data from the National Hospital Morbidity Database. Population data were extracted from the Australian Bureau of Statistics dataset. We analyzed data based on overall trends, type of admissions, and demographics. A total of 1,61,597 hospital admissions MAEs for nonopioid analgesics, antipyretics, and antirheumatics were recorded during study time. The annual number of admissions increased by 43.6%, reflecting a 3.8% increase in the hospital admission rate. The main reason for admissions was MAEs of 4-aminophenol derivatives. Most episodes were overnight admissions. The incidences of admissions were higher among younger age groups and females. Medication administration errors of nonopioid analgesics, antipyretics, and antirheumatics-related hospital admissions rose significantly in Australia. The most common causes of admission were poisonings by 4-aminophenol and other nonsteroidal anti-inflammatory drugs. Admissions are higher in the age group below 20 years and in females. Raising public awareness about medication risks and implementing targeted interventions are required.

摘要

全球范围内药物中毒率持续上升,导致住院人数增加,给卫生系统带来了负担。在澳大利亚,非阿片类镇痛药、退烧药和抗风湿药导致意外中毒的发生率很高。本研究旨在探讨1998年至2022年澳大利亚与非阿片类镇痛药、退烧药和抗风湿药相关的用药错误(用药错误导致的中毒、不良反应和用药不足)导致的住院趋势。这项生态学研究使用了国家医院发病率数据库中的住院数据。人口数据从澳大利亚统计局的数据集中提取。我们根据总体趋势、入院类型和人口统计学特征对数据进行了分析。在研究期间,共记录了161597例因非阿片类镇痛药、退烧药和抗风湿药导致的住院用药错误。入院人数每年增加43.6%,反映出住院率上升了3.8%。入院的主要原因是4-氨基酚衍生物的用药错误。大多数病例是夜间入院。年轻年龄组和女性的入院发生率较高。在澳大利亚,与非阿片类镇痛药、退烧药和抗风湿药相关的住院用药错误显著增加。入院的最常见原因是4-氨基酚和其他非甾体抗炎药中毒。20岁以下年龄组和女性的入院率较高。需要提高公众对用药风险的认识并实施有针对性的干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e08/12173260/9ff06c38ce3a/medi-104-e42893-g001.jpg

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