Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Isra University Faculty of Pharmacy, Amman, Jordan.
Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
BMJ Open. 2023 Nov 19;13(11):e079932. doi: 10.1136/bmjopen-2023-079932.
To explore the correlation between prescribing rate of medications and hospital admissions related to medications administration errors in England and Wales during the time from 1999 to 2020.
An ecological study.
A population-based study using hospital admission data that are publicly available in the UK. Data in this study were extracted from the Hospital Episode Statistics database in England and the Patient Episode Database in Wales from Wales. The Prescription Cost Analysis database was used to extract the prescription data.
Patients who were hospitalised all National Health Service (NHS) trusts and any independent sector funded by NHS trusts.
Hospitalisation rates related to medication administration errors and its associated prescriptions.
The annual rate of hospital admissions related to medication administration errors increased by 32.0% (from 184.21 (95% CI 183.0 to 185.4) in 1999 to 243.18 (95% CI 241.9 to 244.4) in 2020 per 100 000 persons. The most common three indications of hospital admissions were T39 (non-opioid analgesics, antipyretics and antirheumatics), T43 (psychotropic drugs), T42 (antiepileptic, sedative-hypnotic and antiparkinsonism drugs). The age group 15-59 years had the highest number of hospital admissions (83.4%). Women contributed to 59.1% of the total number of hospital admissions. Admission rate among men increased by 16.7%. Among women, the admission rate increased by 44.6%.
Admission rates due to medication administration errors increased markedly in the past decade. This increase was correlated with an increase in the prescription rate of several therapeutic classes. Patients taking non-opioid analgesics, antipyretics and antirheumatics, psychiatric medications, antiepileptic, sedative-hypnotic and antiparkinsonism drugs should have their recommended (and administered) doses closely monitored. They should be followed up on a regular basis to ensure that they are taking their medications as prescribed.
探索 1999 年至 2020 年期间英格兰和威尔士药物管理错误相关药物处方率与住院率之间的相关性。
生态研究。
使用英国公开的医院入院数据进行基于人群的研究。本研究的数据从英格兰的医院入院统计数据库和威尔士的患者入院数据库中提取，处方数据从处方成本分析数据库中提取。
在所有国民保健服务（NHS）信托机构住院的患者，以及由 NHS 信托机构资助的任何独立部门的患者。
药物管理错误相关的住院率及其相关处方。
药物管理错误相关的住院率每年增加 32.0%（从 1999 年的每 10 万人 184.21（95%CI 183.0 至 185.4）增加到 2020 年的 243.18（95%CI 241.9 至 244.4））。最常见的三种住院原因是 T39（非阿片类镇痛药、解热药和抗风湿药）、T43（精神药物）和 T42（抗癫痫药、镇静催眠药和抗帕金森病药物）。年龄在 15-59 岁的人群中住院人数最多（83.4%）。女性占总住院人数的 59.1%。男性的入院率增加了 16.7%。女性的入院率增加了 44.6%。
过去十年中，因药物管理错误导致的入院率显著增加。这种增加与一些治疗类别的处方率增加有关。服用非阿片类镇痛药、解热药和抗风湿药、精神药物、抗癫痫药、镇静催眠药和抗帕金森病药物的患者应密切监测其推荐（和给予）剂量。应定期对他们进行随访，以确保他们按规定服用药物。
