Ono T, Nakamura K
Brain Res. 1985 Nov 4;346(2):368-73. doi: 10.1016/0006-8993(85)90872-8.
Single neuron activity was recorded in the lateral hypothalamus (LHA) and lateral preoptic-anterior hypothalamic area (IPOA-AHA) of the rat during discrimination learning of cue tones that predicted glucose or intracranial self-stimulation as rewarding stimuli, or electric shock or tail pinch as aversive stimuli, using identical behavior, licking. Rewarding and aversive stimuli had opposite effects on the same LHA neurons, but had the same effects on IPOA-AHA neurons. Neurons in the LHA that differentiated between reward and aversion acquired discrimination of the respective cue tones, while IPOA-AHA neurons responded in the same way to cue tones whether they preceded reward or aversion. The results suggest reward- and aversion-related integrative functions in the LHA and arousal or attentional functions in the IPOA-AHA.
在大鼠辨别学习提示音的过程中，记录其外侧下丘脑（LHA）和外侧视前 - 下丘脑前部区域（IPOA - AHA）的单神经元活动。提示音可预测葡萄糖或颅内自我刺激作为奖励性刺激，或电击或夹尾作为厌恶性刺激，采用相同的行为即舔舐。奖励性和厌恶性刺激对同一LHA神经元具有相反的作用，但对IPOA - AHA神经元具有相同的作用。LHA中区分奖励和厌恶的神经元获得了对各自提示音的辨别能力，而IPOA - AHA神经元对提示音的反应方式相同，无论提示音在奖励或厌恶之前出现。结果表明LHA中存在与奖励和厌恶相关的整合功能，而IPOA - AHA中存在觉醒或注意力功能。
