Schwartzbaum J S, Leventhal T O
Department of Psychology, University of Rochester, NY 14627.
Brain Res. 1990 Jan 15;507(1):85-91. doi: 10.1016/0006-8993(90)90525-g.
Unit electrophysiology of lateral hypothalamus (LH) in rabbits has revealed two functionally contrasting, topographically distinguishable groups of neurons that relate to hedonic properties of taste stimuli. To assess the neurobehavioral role of aversion-type cells (maximally excited by aversive stimuli and inhibited by rewarding stimuli) found in the rostral part of mid-lateral LH at the level of ventromedial nucleus (vmh), intracranial self stimulation (ICSS) and stimulation-escape were studied with moveable-type electrodes in this and an adjoining caudal region of LH dominated by a contrasting type of neuron. Hedonic properties of the brain stimulation conformed to the distribution of these cellular elements. Stimulation of the rostral area supported weaker ICSS and stronger escape behavior. Aversive reactions predominated in ventral parts of the rostral area. Aversion-type cells identified electrophysiologically in this region would appear to mediate behaviorally aversive functions. These cells may play a role in the activation of feeding (possibly also drinking) and in drive-reduction reward.
对兔下丘脑外侧区（LH）的单位电生理研究揭示，存在两组功能相反、在地形学上可区分的神经元，它们与味觉刺激的享乐特性有关。为评估在腹内侧核（vmh）水平的中外侧LH前部发现的厌恶型细胞（对厌恶刺激最大程度兴奋，对奖赏刺激抑制）的神经行为作用，本研究使用可移动电极在该区域以及相邻的LH尾部区域（以对比类型的神经元为主）研究了颅内自我刺激（ICSS）和刺激逃避。脑刺激的享乐特性符合这些细胞成分的分布。刺激前部区域支持较弱的ICSS和较强的逃避行为。厌恶反应在该区域前部的腹侧部分占主导。在该区域通过电生理学鉴定的厌恶型细胞似乎在行为上介导厌恶功能。这些细胞可能在进食（可能还有饮水）的激活以及驱力降低奖赏中发挥作用。
