Park Yunjeong, Jeong Heechul, Shin Jung-Ho, Cho Geum Joon, Kim Yong Jin
Department of Obstetrics and Gynecology, Yonsei University, Seoul, Korea.
Department of Statistics, Sungkyunkwan University, Seoul, Korea.
J Assist Reprod Genet. 2025 Jun 17. doi: 10.1007/s10815-025-03542-1.
To investigate the association of ovarian hyperstimulation syndrome (OHSS) and adverse maternal and neonatal outcomes.
This retrospective study used combined Korea National Health Insurance (KNHI) claims and National Health Screening Program for Infants and Children data. Women who gave birth through in vitro fertilization using fresh embryo transfer during 2017-2022 were enrolled. Z-scores were calculated. Student's t-test, analysis of variance, Pearson's chi-squared (χ) test, and multivariate logistic regression analyses were performed.
The non-OHSS group included 27,337 women, while the OHSS group included 1,570 women (mild to moderate, 1,308; severe, 262). The OHSS group was significantly younger (34.86 ± 3.54 vs. 36.21 ± 3.58 years, p < 0.0001) and had significantly higher rates of primiparity, cesarean section, and polycystic ovary syndrome (88.98% vs. 82.89%, p < 0.0001; 75.8% vs. 65.75%, p < 0.0001; and 29.24% vs. 14.37%, p < 0.0001, respectively). OHSS was associated with a decreased incidence of low birth weight and with an increased incidence of macrosomia (adjusted odds ratio [95% confidence interval], 0.53 [0.38-0.72], p < 0.0001; and 1.83 [1.42-2.35], p < 0.0001). OHSS was associated with an increased incidence of transient tachypnea of the newborn (TTN) and respiratory distress syndrome (RDS) (1.32 [1.02-1.71], p = 0.03; and 1.57 [1.30-1.91], p < 0.0001).
OHSS is associated with a decreased incidence of low birth weight and an increased incidence of macrosomia, TTN, and RDS.
探讨卵巢过度刺激综合征（OHSS）与孕产妇及新生儿不良结局之间的关联。
本回顾性研究使用了韩国国民健康保险（KNHI）理赔数据和国家婴幼儿健康筛查计划数据。纳入了2017年至2022年期间通过新鲜胚胎移植进行体外受精分娩的女性。计算了Z分数。进行了学生t检验、方差分析、Pearson卡方（χ）检验和多因素逻辑回归分析。
非OHSS组包括27337名女性，而OHSS组包括1570名女性（轻度至中度1308名；重度262名）。OHSS组明显更年轻（34.86±3.54岁 vs. 36.21±3.58岁，p<0.0001），初产、剖宫产和多囊卵巢综合征的发生率显著更高（分别为88.98% vs. 82.89%，p<0.0001；75.8% vs. 65.75%，p<0.0001；29.24% vs. 14.37%，p<0.0001）。OHSS与低出生体重发生率降低以及巨大儿发生率增加相关（校正优势比[95%置信区间]，0.53[0.38 - 0.72]，p<0.0001；1.83[1.42 - 2.35]，p<0.0001）。OHSS与新生儿短暂性呼吸急促（TTN）和呼吸窘迫综合征（RDS）的发生率增加相关（1.32[1.02 - 1.71]，p = 0.03；1.57[1.30 - 1.91]，p<0.0001）。
OHSS与低出生体重发生率降低以及巨大儿、TTN和RDS发生率增加相关。
