Kim Ju Hee, Lee Jung Eun, Shim So Min, Ha Eun Kyo, Yon Dong Keon, Kim Ok Hyang, Baek Ji Hyeon, Koh Hyun Yong, Chae Kyu Young, Lee Seung Won, Han Man Yong
Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Department of Data Science, Sejong University College of Software Convergence, Seoul, Korea.
Clin Exp Pediatr. 2021 Sep;64(9):480-488. doi: 10.3345/cep.2020.01284. Epub 2021 Jan 5.
An adequate large-scale pediatric cohort based on nationwide administrative data is lacking in Korea.
This study established the National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008) based on data from a nationwide population-based health screening program and data on healthcare utilization for children.
The NICKs-2008 study consisted of the Korean National Health Insurance System (NHIS) and the National Health Screening Program for Infants and Children (NHSPIC) databases comprising children born in 2008 (n=469,248) and 2009 (n=448,459) in the Republic of Korea. The NHIS database contains data on age, sex, residential area, income, healthcare utilization (International Classification of Diseases-10 codes, procedure codes, and drug classification codes), and healthcare providers. The NHSPIC consists of 7 screening rounds. These screening sessions comprised physical examination, developmental screening (rounds 2-7), a general health questionnaire, and age-specific anticipatory guidance.
During the 10-year follow-up, 2,718 children (0.3%) died, including more boys than girls (hazard ratio, 1.145; P<0.001). A total of 848,048 children participated in at least 1 of the 7 rounds of the NHSPIC, while 96,046 participated in all 7 screening programs. A total of 823 infants (0.1%) weighed less than 1,000 g, 3,177 (0.4%) weighed 1,000-1,499 g, 37,166 (4.4%) weighed 1,500-2,499 g, 773,081 (91.4%) weighed 2,500-4,000 g, and 32,016 (5.1%) weighed over 4,000 g. There were 23,404 premature babies (5.5%) in 2008 compared to 23,368 (5.6%) in 2009. The developmental screening test indicated appropriate development in 95%-98% of children, follow-up requirements for 1%-4% of children, and recommendations for further evaluation for 1% of children.
The NICKs-2008, which integrates data from the NHIS and NHSPIC databases, can be used to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors.
韩国缺乏基于全国行政数据的足够大规模儿科队列。
本研究基于全国性的基于人群的健康筛查项目数据和儿童医疗保健利用数据，建立了2008年韩国出生队列全国调查研究（NICKs - 2008）。
NICKs - 2008研究由韩国国民健康保险系统（NHIS）和婴幼儿及儿童全国健康筛查项目（NHSPIC）数据库组成，包含大韩民国2008年出生的儿童（n = 469,248）和2009年出生的儿童（n = 448,459）。NHIS数据库包含年龄、性别、居住地区、收入、医疗保健利用情况（国际疾病分类 - 10编码、程序编码和药物分类编码）以及医疗保健提供者的数据。NHSPIC包括7轮筛查。这些筛查环节包括体格检查、发育筛查（第2 - 7轮）、一份一般健康问卷以及针对特定年龄的预期指导。
在10年随访期间，2718名儿童（0.3%）死亡，其中男孩死亡人数多于女孩（风险比，1.145；P < 0.001）。共有848,048名儿童参加了NHSPIC的7轮筛查中的至少1轮，而96,046名儿童参加了全部7项筛查项目。共有823名婴儿（0.1%）体重低于1000克，3177名（0.4%）体重为1000 - 1499克，37,166名（4.4%）体重为1500 - 2499克，773,081名（91.4%）体重为2500 - 4000克，32,016名（5.1%）体重超过4000克。2008年有23,404名早产儿（5.5%），2009年有23,368名（5.6%）。发育筛查测试表明95% - 98%的儿童发育正常，1% - 4%的儿童需要随访，1%的儿童需要进一步评估建议。
整合了NHIS和NHSPIC数据库数据的NICKs - 2008可用于根据生活方式、饮食习惯和风险因素等信息分析住院前的疾病发病情况。
