Sharpe L G, Pickworth W B
Brain Res Bull. 1985 Sep;15(3):329-33. doi: 10.1016/0361-9230(85)90159-5.
The Edinger-Westphal complex (EW) was explored as a possible site of action for the effects of morphine and clonidine to produce mydriasis in the cat and miosis in the dog. Morphine, normorphine and clonidine, dissolved in 0.5 microliter 0.9% NaCl, were injected via chronic indwelling cannulae into or near the EW of the restrained cat and dog. In the cat, all 3 drugs produced a dose-dependent mydriasis. Clonidine (3-30 nmol) was 1.7 times more potent than normorphine (3-30 nmol) and 9.6 times more potent than morphine (10-60 nmol). Normorphine was 5.5 times more potent than morphine. Significant miosis resulted from single doses of morphine (17.5 nmol), normorphine (15.5 nmol) and clonidine (19 nmol) injected in the EW of the dog. Injections sites closest to the EW yielded the greatest changes in pupillary diameter. Naloxone antagonized the pupillary effects of normorphine in the cat and dog but had no effect on clonidine mydriasis in one cat. It was concluded that the EW region is an important site of action for the effects of morphine and clonidine on pupil diameter in both species. However, the neurocircuitry and neurochemistry of the EW probably differ between the cat and dog.
研究了动眼神经副核复合体（EW）作为吗啡和可乐定产生作用的可能位点，这些作用分别是使猫瞳孔散大以及使犬瞳孔缩小。将溶解于0.5微升0.9%氯化钠溶液中的吗啡、去甲吗啡和可乐定，通过慢性留置套管注射到被束缚的猫和犬的EW内或其附近。在猫中，所有这三种药物均产生剂量依赖性瞳孔散大。可乐定（3 - 30纳摩尔）的效力比去甲吗啡（3 - 30纳摩尔）强1.7倍，比吗啡（10 - 60纳摩尔）强9.6倍。去甲吗啡的效力比吗啡强5.5倍。向犬的EW内单次注射吗啡（17.5纳摩尔）、去甲吗啡（15.5纳摩尔）和可乐定（19纳摩尔）会导致明显的瞳孔缩小。最靠近EW的注射部位使瞳孔直径变化最大。纳洛酮拮抗了猫和犬中去甲吗啡的瞳孔效应，但对一只猫的可乐定引起的瞳孔散大没有影响。得出的结论是，EW区域是吗啡和可乐定对两种动物瞳孔直径产生作用的重要作用位点。然而，猫和犬的EW的神经回路和神经化学可能不同。
