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新型吲哚衍生物作为用于治疗精神病、精神疾病和中枢神经系统疾病的血清素能致幻剂。

Novel Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2025 May 30;16(6):982-983. doi: 10.1021/acsmedchemlett.5c00309. eCollection 2025 Jun 12.

Abstract

Provided herein are novel indole derivatives as serotonergic psychedelic agents, pharmaceutical compositions, use of such compounds in treating psychosis, mental illness and central nervous system (CNS) disorders, and processes for preparing such compounds.

摘要

本文提供了作为血清素能致幻剂的新型吲哚衍生物、药物组合物、此类化合物在治疗精神病、精神疾病和中枢神经系统(CNS)疾病中的用途,以及制备此类化合物的方法。

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本文引用的文献

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5-HT receptors: Pharmacology and functional selectivity.
Pharmacol Rev. 2025 Jul;77(4):100059. doi: 10.1016/j.pharmr.2025.100059. Epub 2025 Apr 23.
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The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.
Psychopharmacology (Berl). 2025 Apr 11. doi: 10.1007/s00213-025-06777-z.
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Novel Compounds as 5-HT2A Agonists for Treating Mental Illness or CNS Disorders.
ACS Med Chem Lett. 2025 Feb 11;16(3):377-378. doi: 10.1021/acsmedchemlett.5c00066. eCollection 2025 Mar 13.
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Exploring DMT: Endogenous role and therapeutic potential.
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