靶向雌激素受体α治疗乳腺癌的新型四氢环庚烯吲哚衍生物
Novel Tetrahydrocyclohepteneindole Derivatives Targeting Estrogen Receptor Alpha for the Treatment of Breast Cancer.
作者信息
Song Zhendong, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 May 28;16(6):967-969. doi: 10.1021/acsmedchemlett.5c00283. eCollection 2025 Jun 12.
Abstract
This patent presents novel substituted tetrahydrocyclohepteneindole derivatives as selective estrogen receptor alpha (ERα) inhibitors. These compounds demonstrate potential for treating Erα-related diseases such as cancers, ovulatory dysfunction, endometriosis, and inflammation diseases.
摘要
本专利提出了新型取代四氢环庚烯吲哚衍生物作为选择性雌激素受体α（ERα）抑制剂。这些化合物显示出治疗与ERα相关疾病的潜力，如癌症、排卵功能障碍、子宫内膜异位症和炎症性疾病。
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