松弛素家族肽受体1（RXFP1）激动剂作为心力衰竭的潜在治疗方法。
The Relaxin Family Peptide Receptor 1 (RXFP1) Agonists as Potential Treatment for Heart Failure.
作者信息
Abdel-Magid Ahmed F
机构信息
Independent Consultant, 1383 Jasper Drive, Ambler, Pennsylvania 19002, United States.
出版信息
ACS Med Chem Lett. 2025 May 23;16(6):955-958. doi: 10.1021/acsmedchemlett.5c00273. eCollection 2025 Jun 12.
Abstract
The invention in this patent application relates to bicyclo[2.2.1]-heptane derivatives represented herein by formula 1. The compounds of formula 1 are relaxin family peptide receptor 1 (RXFP1) agonists and may provide treatments for heart failure, fibrotic diseases, and related diseases such as lung, kidney, and hepatic diseases.
摘要
本专利申请中的发明涉及本文中式1所示的双环[2.2.1]庚烷衍生物。式1的化合物是松弛素家族肽受体1（RXFP1）激动剂，可用于治疗心力衰竭、纤维化疾病以及相关疾病，如肺部、肾脏和肝脏疾病。
相似文献
1
The Relaxin Family Peptide Receptor 1 (RXFP1) Agonists as Potential Treatment for Heart Failure.松弛素家族肽受体1（RXFP1）激动剂作为心力衰竭的潜在治疗方法。
ACS Med Chem Lett. 2025 May 23;16(6):955-958. doi: 10.1021/acsmedchemlett.5c00273. eCollection 2025 Jun 12.
2
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases.环状GMP-AMP合酶（cGAS）抑制剂作为自身免疫性和炎性疾病的潜在治疗方法
ACS Med Chem Lett. 2024 Aug 22;15(9):1424-1426. doi: 10.1021/acsmedchemlett.4c00392. eCollection 2024 Sep 12.
3
The quantity, quality and findings of network meta-analyses evaluating the effectiveness of GLP-1 RAs for weight loss: a scoping review.评估胰高血糖素样肽-1受体激动剂（GLP-1 RAs）减肥效果的网状Meta分析的数量、质量及结果：一项范围综述
Health Technol Assess. 2025 Jun 25:1-73. doi: 10.3310/SKHT8119.
4
AMP-Activated Protein Kinase Activators as Therapeutic Targets To Treat Heart Failure and Diseases That Can Benefit from Improved Muscular Performance.AMP激活蛋白激酶激活剂作为治疗心力衰竭和可从改善肌肉性能中获益的疾病的治疗靶点。
ACS Med Chem Lett. 2025 Jan 28;16(2):207-209. doi: 10.1021/acsmedchemlett.5c00025. eCollection 2025 Feb 13.
5
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
6
Glucagon-like peptide 1 (GLP-1) receptor agonists for people with chronic kidney disease and diabetes.用于慢性肾病和糖尿病患者的胰高血糖素样肽1（GLP-1）受体激动剂。
Cochrane Database Syst Rev. 2025 Feb 18;2(2):CD015849. doi: 10.1002/14651858.CD015849.pub2.
7
Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) as Treatment for Inflammatory Diseases.丝裂原活化蛋白激酶激活的蛋白激酶2（MK2）抑制剂作为炎症性疾病的治疗方法
ACS Med Chem Lett. 2024 Aug 23;15(9):1421-1423. doi: 10.1021/acsmedchemlett.4c00393. eCollection 2024 Sep 12.
8
Upcoming drug targets for kidney protective effects in chronic kidney disease.慢性肾脏病中具有肾脏保护作用的潜在药物靶点。
Nephrol Dial Transplant. 2025 Feb 5;40(Supplement_1):i47-i58. doi: 10.1093/ndt/gfae216.
9
SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes: a clinical practice guideline.钠-葡萄糖协同转运蛋白 2 抑制剂或胰高血糖素样肽-1 受体激动剂治疗 2 型糖尿病成人患者：临床实践指南。
BMJ. 2021 May 11;373:n1091. doi: 10.1136/bmj.n1091.
10
The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases.盐诱导激酶（SIKs）抑制剂作为炎症、过敏、自身免疫、癌症和代谢性疾病新兴治疗方法的应用
ACS Med Chem Lett. 2025 May 20;16(6):952-954. doi: 10.1021/acsmedchemlett.5c00274. eCollection 2025 Jun 12.
本文引用的文献
1
Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives.松弛素-2 的心血管作用：治疗潜力和未来展望。
Clin Res Cardiol. 2024 Aug;113(8):1137-1150. doi: 10.1007/s00392-023-02305-1. Epub 2023 Sep 18.
2
Relaxin-2 as a Potential Biomarker in Cardiovascular Diseases.松弛素-2作为心血管疾病的潜在生物标志物
J Pers Med. 2022 Jun 21;12(7):1021. doi: 10.3390/jpm12071021.
3
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease.松弛素家族肽受体 1（RXFP1）：人类健康与疾病中的新兴角色。
Mol Genet Genomic Med. 2020 Apr;8(4):e1194. doi: 10.1002/mgg3.1194. Epub 2020 Feb 26.
4
Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases.瑞马唑仑作为一种新型治疗药物，可拮抗肺部疾病中的纤维化和收缩。
Pharmacol Ther. 2018 Jul;187:61-70. doi: 10.1016/j.pharmthera.2018.02.004. Epub 2018 Feb 12.
5
The human insulin superfamily of polypeptide hormones.多肽激素的人类胰岛素超家族。
Vitam Horm. 2009;80:1-31. doi: 10.1016/S0083-6729(08)00601-8.
Zotero 插件