Irawan Budi, Tjokroprawiro Brahmana Askandar, Saraswati Wita, Yuliati Indra, Mulawardhana Pungky, Utomo Budi, Ariani Grace
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, East Java 60286, Indonesia.
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Airlangga University Academic Hospital, Surabaya, East Java 60115, Indonesia.
Mol Clin Oncol. 2025 Jun 4;23(2):70. doi: 10.3892/mco.2025.2865. eCollection 2025 Aug.
Epithelial ovarian carcinoma (EOC) is the most common form of ovarian cancer and is associated with a poor prognosis. Astrocyte Elevated Gene-1 (AEG-1) is an oncogene implicated in cancer cell growth and progression. The present study examined AEG-1 expression in EOC, specifically comparing high-grade serous ovarian carcinoma (HGSOC) and low-grade serous ovarian carcinoma (LGSOC). The present retrospective analytical study employed a cross-sectional design and included women diagnosed with HGSOC or LGSOC between January 2021 and December 2023. Extracted data included demographic, laboratory and clinicopathological characteristics. In addition to comparing AEG-1 expression in HGSOC and LGSOC, associations between these histological subtypes and the extracted variables, as well as associations between AEG-1 expression and these variables, were assessed. Of the 74 patients initially identified, 24 were excluded, resulting in a final sample of 50 patients 23 with LGSOC and 27 with HGSOC. A statistically significant association was found between residual disease and cancer histopathology [odds ratio: 7.219; 95% confidence interval (CI): 1.399-37.252; P=0.024), whereas no significant associations were observed with other variables. AEG-1 expression was significantly higher in HGSOC compared with LGSOC (relative risk: 3.228; 95% CI: 1.188-8.776; P=0.012), with high AEG-1 expression observed more frequently in HGSOC (65.7%) than in LGSOC (34.3%). In conclusion, AEG-1 expression was significantly elevated in HGSOC compared with LGSOC, suggesting a potential role for AEG-1 in the progression of HGSOC.
上皮性卵巢癌（EOC）是卵巢癌最常见的形式，且预后较差。星形胶质细胞上调基因1（AEG-1）是一种与癌细胞生长和进展相关的癌基因。本研究检测了EOC中AEG-1的表达，特别比较了高级别浆液性卵巢癌（HGSOC）和低级别浆液性卵巢癌（LGSOC）。本回顾性分析研究采用横断面设计，纳入了2021年1月至2023年12月期间被诊断为HGSOC或LGSOC的女性。提取的数据包括人口统计学、实验室和临床病理特征。除了比较HGSOC和LGSOC中AEG-1的表达外，还评估了这些组织学亚型与提取变量之间的关联，以及AEG-1表达与这些变量之间的关联。在最初确定的74例患者中，排除了24例，最终样本为50例患者，其中23例为LGSOC，27例为HGSOC。发现残留病灶与癌症组织病理学之间存在统计学显著关联[比值比：7.219；95%置信区间（CI）：1.399 - 37.252；P = 0.024]，而与其他变量未观察到显著关联。与LGSOC相比，HGSOC中AEG-1表达显著更高（相对风险：3.228；95% CI：1.188 - 8.776；P = 0.012），HGSOC中高AEG-1表达的发生率（65.7%）高于LGSOC（34.3%）。总之，与LGSOC相比，HGSOC中AEG-1表达显著升高，提示AEG-1在HGSOC进展中可能发挥作用。
