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通过细菌诱导生物矿化优化新型牙科自修复树脂复合材料

Optimization of a novel dental self-healing resin composite by bacteria-induced biomineralization.

作者信息

Han Yanyan, Zhang Xiaoxuan, Weng Jianing, Tian Shiqi, Dong Xian, Cai Zhiheng, Zhang Yi, Wu Tiantian, Lin Dan, Zhu Yaqin

机构信息

Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.

出版信息

Front Bioeng Biotechnol. 2025 Jun 2;13:1590348. doi: 10.3389/fbioe.2025.1590348. eCollection 2025.

DOI:10.3389/fbioe.2025.1590348
PMID:40529175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12171228/
Abstract

INTRODUCTION

Dental resin restorations often fail due to microcrack expansion, causing fractures and secondary caries. Self-healing resin composites based on Microbially Induced Calcium Carbonate Precipitation (MICP) offer a solution. In these composites, moisture and air activate bacteria to precipitate calcium carbonate (CaCO) and repair microcracks. When a crack seals, bacteria become dormant or form spores until the next crack forms, triggering repeated self-healing.

METHODS

This study involved the optimization of nutrients to enhance biocompatibility, the preparation of dental resin composites incorporating eight different bacterial strains, the investigation of Mn to enhance self-healing properties, and the utilization of a method to evaluate self-healing efficiency tailored for the oral environment. This method took a microscopic view of the healing process in artificial saliva, and the self-healing efficiency was determined by quantifying the scratch area.

RESULTS

In the final results, sphaericus (ATCC 4525) cultured with Mn exhibited the most impressive self-healing effect, while pasteurii (B80469) had the weakest self-healing effect in the study. Otherwise, Bifidobacterium longum showed no significant difference between its initial and secondary healing effects.

DISCUSSION

This dental self-healing resin composite can undergo multiple rounds of self-repair and boasts high biocompatibility, leading to a significant reduction in the failure rate of dental resin restorations.

摘要

引言

牙科树脂修复体常常因微裂纹扩展而失败，导致断裂和继发龋。基于微生物诱导碳酸钙沉淀（MICP）的自愈合树脂复合材料提供了一种解决方案。在这些复合材料中，水分和空气激活细菌以沉淀碳酸钙（CaCO）并修复微裂纹。当裂纹封闭时，细菌进入休眠状态或形成孢子，直到下一个裂纹形成，从而触发反复的自我修复。

方法

本研究涉及优化营养成分以提高生物相容性、制备包含八种不同细菌菌株的牙科树脂复合材料、研究锰以增强自我修复性能以及利用一种针对口腔环境量身定制的评估自我修复效率的方法。该方法从微观角度观察人工唾液中的愈合过程，并通过量化划痕面积来确定自我修复效率。

结果

在最终结果中，用锰培养的球形芽孢杆菌（ATCC 4525）表现出最显著的自我修复效果，而巴氏芽孢杆菌（B80469）在该研究中的自我修复效果最弱。此外，长双歧杆菌的初次和二次愈合效果之间没有显著差异。

讨论

这种牙科自愈合树脂复合材料可以进行多轮自我修复，并且具有高生物相容性，从而显著降低牙科树脂修复体的失败率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b99a/12171228/9635cdeff8b5/fbioe-13-1590348-g010.jpg
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本文引用的文献

1
Surface modifications of short quartz fibers and their influence on the physicochemical properties and in vitro cell viability of dental composites.短石英纤维的表面改性及其对牙科复合材料理化性能和体外细胞活力的影响。
Dent Mater. 2024 Aug;40(8):e1-e10. doi: 10.1016/j.dental.2024.05.023. Epub 2024 May 30.
2
How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective.益生菌、益生元、合生元和后生元如何预防龋齿：口腔微生物组视角。
NPJ Biofilms Microbiomes. 2024 Feb 24;10(1):14. doi: 10.1038/s41522-024-00488-7.
3
A comprehensive review of the application of probiotics and postbiotics in oral health.
益生菌和后生元在口腔健康中应用的综合述评。
Front Cell Infect Microbiol. 2023 Mar 8;13:1120995. doi: 10.3389/fcimb.2023.1120995. eCollection 2023.
4
Biocompatible Nanocapsules for Self-Healing Dental Resins and Bone Cements.用于自修复牙科树脂和骨水泥的生物相容性纳米胶囊。
ACS Omega. 2022 Aug 31;7(36):31726-31735. doi: 10.1021/acsomega.2c02080. eCollection 2022 Sep 13.
5
Novel nanoparticle-modified multifunctional microcapsules with self-healing and antibacterial activities for dental applications.新型纳米粒子修饰的多功能微胶囊，具有自修复和抗菌活性，可用于牙科应用。
Dent Mater. 2022 Aug;38(8):1301-1315. doi: 10.1016/j.dental.2022.06.012. Epub 2022 Jun 17.
6
Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis.益生菌预防儿童龋齿的效果：系统评价和荟萃分析。
Crit Rev Food Sci Nutr. 2023;63(29):9977-9994. doi: 10.1080/10408398.2022.2077693. Epub 2022 May 24.
7
Can Probiotics Emerge as Effective Therapeutic Agents in Apical Periodontitis? A Review.益生菌可否成为尖周炎的有效治疗手段？综述。
Probiotics Antimicrob Proteins. 2021 Apr;13(2):299-314. doi: 10.1007/s12602-021-09750-2. Epub 2021 Feb 13.
8
Immobilization and migration of arsenic during the conversion of microbially induced calcium carbonate to hydroxylapatite.微生物诱导碳酸钙转化为羟磷灰石过程中砷的固定和迁移。
J Hazard Mater. 2021 Jun 15;412:125261. doi: 10.1016/j.jhazmat.2021.125261. Epub 2021 Jan 29.
9
Microbially induced calcium carbonate precipitation to design a new type of bio self-healing dental composite.微生物诱导碳酸钙沉淀设计新型生物自修复牙科复合材料。
Appl Microbiol Biotechnol. 2020 Mar;104(5):2029-2037. doi: 10.1007/s00253-019-10345-9. Epub 2020 Jan 15.
10
The pros, cons, and many unknowns of probiotics.益生菌的利与弊及诸多未知因素。
Nat Med. 2019 May;25(5):716-729. doi: 10.1038/s41591-019-0439-x. Epub 2019 May 6.