Xu Rui, Fu Xihong, Lun Lerong, Jiang Wenjing, Situ Xuemei, Huang Xiaobao, Xiong Ying, Liu Chun, Wang Fang
Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Bioact Mater. 2024 Nov 20;45:148-161. doi: 10.1016/j.bioactmat.2024.11.013. eCollection 2025 Mar.
The medicine field continues to encounter obstacles in understanding the etiology of skin inflammation and the process of skin wound repair. Developing sustainable and effective three-dimensional (3D) skin models for investigating inflammatory skin biology remains a challenge. By incorporating halloysite nanotubes (HNT) into a composite collagen/alginate/hyaluronic acid hydrogel, we created a novel 3D skin model and introduced keratinocytes and fibroblast cells into it. We demonstrate that the modified 3D skin model is capable of enhancing the differentiation and adhesion behaviors of keratinocytes and fibroblast cells and promoting wound healing . These characteristics highlight the potential of this approach for the study of skin inflammation, wound healing, regeneration, aging, and beyond.
医学领域在理解皮肤炎症的病因和皮肤伤口修复过程方面仍面临障碍。开发用于研究炎症性皮肤生物学的可持续且有效的三维（3D）皮肤模型仍然是一项挑战。通过将埃洛石纳米管（HNT）纳入复合胶原蛋白/海藻酸盐/透明质酸水凝胶中，我们创建了一种新型3D皮肤模型，并将角质形成细胞和成纤维细胞引入其中。我们证明，这种改良的3D皮肤模型能够增强角质形成细胞和成纤维细胞的分化和黏附行为，并促进伤口愈合。这些特性突出了这种方法在皮肤炎症、伤口愈合、再生、衰老等研究方面的潜力。
