Wu Wangchun, Peng Yanguo, Chen Shuiyu
Department of Neurosurgery, The Affiliated Mindong Hospital of Fujian Medical University, Fu'an, China.
Front Neurol. 2025 Jun 3;16:1582379. doi: 10.3389/fneur.2025.1582379. eCollection 2025.
Several previous studies have suggested that micronutrients with antioxidant properties are protective factors against migraine. Despite being an important dietary antioxidant, the relationship between dietary vitamin E and migraine has not been extensively studied. This study sought to understand the association between dietary vitamin E intake and the incidence of migraine.
Data from the National Health and Nutrition Examination Survey (1999-2004) were used in this cross-sectional analysis. To assess the association between dietary vitamin E intake and migraine, we employed logistic regression, restricted cubic spline regression, and stratified analyses.
This study included 10,063 participants who were 20 years old or older, 20.1% (2018/10,063) of whom reported suffering from migraine. Compared with the lowest vitamin E intake T1 (<4.5 mg/day), the adjusted odds ratios (ORs) of dietary vitamin E intake and migraine for T2 (4.5-7.8 mg/day) and T3 (>7.8 mg/day) were 0.85 (95% confidence interval [CI]: 0.74-0.98, = 0.03) and 0.75 (95% confidence interval [CI]: 0.63-0.90, = 0.001), respectively. An L-shaped nonlinear association existed between dietary vitamin E consumption and migraines ( = 0.006). For participants who consumed <7.3 mg of vitamin E daily, the OR for migraine was 0.92 (95% CI: 0.874-0.969, = 0.0015). When daily vitamin E intake was ≥7.3 mg/day, the risk of migraine did not continue to decrease with increasing dietary vitamin E consumption (OR, 1.008; 95% CI, 0.984-1.033). The results of the sensitivity analysis suggest that the association between dietary vitamin E intake and migraine remains robust.
In adults, the association between dietary vitamin E intake and migraine is an L-shaped curve (nonlinear, = 0.006), with an inflection point at 7.3 mg/day. It reminds individuals to keep diets balanced.
此前的多项研究表明，具有抗氧化特性的微量营养素是偏头痛的保护因素。尽管膳食维生素E是一种重要的膳食抗氧化剂，但膳食维生素E与偏头痛之间的关系尚未得到广泛研究。本研究旨在了解膳食维生素E摄入量与偏头痛发病率之间的关联。
本横断面分析使用了美国国家健康与营养检查调查（1999 - 2004年）的数据。为评估膳食维生素E摄入量与偏头痛之间的关联，我们采用了逻辑回归、受限立方样条回归和分层分析。
本研究纳入了10063名20岁及以上的参与者，其中20.1%（2018/10063）报告患有偏头痛。与维生素E摄入量最低的T1组（<4.5毫克/天）相比，T2组（4.5 - 7.8毫克/天）和T3组（>7.8毫克/天）膳食维生素E摄入量与偏头痛的校正比值比（OR）分别为0.85（95%置信区间[CI]：0.74 - 0.98，P = 0.03）和0.75（95%置信区间[CI]：0.63 - 0.90，P = 0.001）。膳食维生素E摄入量与偏头痛之间存在L形非线性关联（P = 0.006）。对于每日维生素E摄入量<7.3毫克的参与者，偏头痛的OR为0.92（95% CI：0.874 - 0.969，P = 0.0015）。当每日维生素E摄入量≥7.3毫克/天时，偏头痛风险并未随着膳食维生素E摄入量的增加而继续降低（OR，1.008；95% CI，0.984 - 1.033）。敏感性分析结果表明，膳食维生素E摄入量与偏头痛之间的关联仍然稳健。
在成年人中，膳食维生素E摄入量与偏头痛之间的关联呈L形曲线（非线性，P = 0.006），拐点为7.3毫克/天。这提醒人们保持饮食均衡。
