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在镍钛根管器械可能暴露于朊病毒后的胍基硫氰酸盐去污材料兼容性

Material compatibility of guanidine thiocyanate for decontamination of nickel-titanium root canal instruments after potential exposure to prions.

作者信息

Boldt Anne-Maria, Schulz-Schaeffer Walter J, Benkhai Hicham, Kramer Axel

机构信息

Sanitätsversorgungszentrum, Storkow, Germany.

Institute of Neuropathology, Medical Faculty of the Saarland University, Homburg, Germany.

出版信息

GMS Hyg Infect Control. 2025 May 12;20:Doc19. doi: 10.3205/dgkh000548. eCollection 2025.

DOI:10.3205/dgkh000548
PMID:40529468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12171978/
Abstract

AIM

Due to the effectiveness of guanidine thiocyanate (GdnSCN) for the decontamination of prion protein aggregates, which are the causative agent of transmissible spongiform encephalopathy, the influence on the bending stiffness and torsional strength of endodontic nickel-titanium files should be tested to provide a potential alternative to single-use if necessary.

METHOD

For the investigation, nitrite-titanium-coated EasyShape files of sizes 25.06 and 35.04 were placed in 6 M GdnSCN solution 8 times for 15 min each for decontamination in line with the manufacturer's recommendation, with intermediate drying in each case. To simulate the worst case, the soaking time was extended to 12 h once. Both the bending stiffness and the torsional and fracture behavior were determined in accordance with DIN EN ISO 3630-1:2008-04.

RESULTS

Compared to the untreated control (n=12), decontamination with GdnSCN has no effect on the torsional strength or flexural rigidity of the tested endodontic instruments of sizes 25.06 and 35.04 (n=18 each) when used properly. On the other hand, the exposure time of 12 h reduced the bending moment and torsion angle of instrument size 25.06, while the material properties of size 35.04 files are not affected.

DISCUSSION

Based on the results, the maximum 8-fold application of 6 M GdnSCN solution for 15 min for decontamination of endodontic nickel-titanium files can be considered. Although the sterilization process has no influence on the fracture behavior, it is important to clarify for clinical practice what influence the overall reprocessing process has on the performance of the instruments.

摘要

目的

由于硫氰酸胍（GdnSCN）对朊病毒蛋白聚集体（可传播性海绵状脑病的病原体）具有去污作用，因此应测试其对牙髓镍钛锉弯曲刚度和扭转强度的影响，以便在必要时提供一次性使用的潜在替代方案。

方法

为进行此项研究，将尺寸为25.06和35.04的亚硝酸钛涂层EasyShape锉按照制造商的建议，在6 M GdnSCN溶液中放置8次，每次15分钟进行去污处理，每次处理之间进行中间干燥。为模拟最坏情况，浸泡时间延长至12小时一次。弯曲刚度、扭转和断裂行为均按照DIN EN ISO 3630-1:2008-04进行测定。

结果

与未处理的对照组（n = 12）相比，正确使用时，用GdnSCN去污对尺寸为25.06和35.04的受试牙髓器械（每组n = 18）的扭转强度或弯曲刚度没有影响。另一方面，12小时的暴露时间降低了尺寸为25.06器械的弯矩和扭转角度，而尺寸为35.04的锉的材料性能不受影响。

讨论

基于这些结果，可以考虑对牙髓镍钛锉进行去污时，将6 M GdnSCN溶液最多应用8次，每次15分钟。尽管灭菌过程对断裂行为没有影响，但对于临床实践而言，明确整个再处理过程对器械性能有何影响非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/66fe8493c948/HIC-20-19-g-009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/23674c8e2d7b/HIC-20-19-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/a13a696eceba/HIC-20-19-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/f3efcb9d9737/HIC-20-19-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/345abe8bf7e6/HIC-20-19-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/ae023b8d0ca8/HIC-20-19-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/d421fbe0afde/HIC-20-19-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/5c286922a0fb/HIC-20-19-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/f80e800c0333/HIC-20-19-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/e933d2ca1b33/HIC-20-19-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/efe205ad85ca/HIC-20-19-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/989c6dacec2c/HIC-20-19-g-008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/66fe8493c948/HIC-20-19-g-009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/23674c8e2d7b/HIC-20-19-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/a13a696eceba/HIC-20-19-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/f3efcb9d9737/HIC-20-19-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/345abe8bf7e6/HIC-20-19-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/ae023b8d0ca8/HIC-20-19-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/d421fbe0afde/HIC-20-19-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/5c286922a0fb/HIC-20-19-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/f80e800c0333/HIC-20-19-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/e933d2ca1b33/HIC-20-19-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/efe205ad85ca/HIC-20-19-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/989c6dacec2c/HIC-20-19-g-008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51a1/12171978/66fe8493c948/HIC-20-19-g-009.jpg

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