Phillips B, Marshall M E, Brown S, Thompson J S
Cancer. 1985 Dec 15;56(12):2789-92. doi: 10.1002/1097-0142(19851215)56:12<2789::aid-cncr2820561213>3.0.co;2-2.
Natural killer (NK) cells play a central role in immune surveillance against tumors and viral infections. NK activity is depressed in patients who have a wide range of carcinomas, including carcinomas of the lung. Peripheral blood NK activity was measured in 22 nonsmokers, 15 light/moderate smokers, 12 heavy smokers, and 19 patients with carcinoma of the lung. Patients with carcinoma of the lung had marked depression in NK activity compared with nonsmokers. Light/moderate smokers had NK activity comparable to that of nonsmokers, whereas heavy smokers had marked depression in NK activity that was comparable to that of patients with carcinoma of the lung. These results suggest that smoking-induced alterations in NK activity may have a role in the pathogenesis of smoking-associated carcinoma of the lung.
自然杀伤（NK）细胞在针对肿瘤和病毒感染的免疫监视中发挥核心作用。NK活性在患有多种癌症（包括肺癌）的患者中会降低。对22名不吸烟者、15名轻度/中度吸烟者、12名重度吸烟者和19名肺癌患者的外周血NK活性进行了测量。与不吸烟者相比，肺癌患者的NK活性明显降低。轻度/中度吸烟者的NK活性与不吸烟者相当，而重度吸烟者的NK活性明显降低，与肺癌患者相当。这些结果表明，吸烟引起的NK活性改变可能在吸烟相关肺癌的发病机制中起作用。
