Saito T, Iizuka T, Kato H, Watanabe H
Cancer. 1985 Nov 1;56(9):2235-41. doi: 10.1002/1097-0142(19851101)56:9<2235::aid-cncr2820560917>3.0.co;2-0.
Esophageal carcinoma metastatic to the stomach was analyzed in 35 patients. Ten were discovered in surgical specimens and 25 at autopsy. All patients were men with a mean age of 62 years. Primary lesions were most frequently located in the middle of thoracic esophagus and were larger than 7 cm. Undifferentiated carcinoma was found in 29% of the patients. Local spread of the primary lesions to neighboring structures was seen in 34%. Lymphatic invasion, and intramural metastases within the esophagus, as well as lymph node metastases, were predominant. Metastatic lesions within the stomach were mostly located in the gastric cardia, were less than 2 cm or more than 4 cm in size, and resembled submucosal tumors. Gastric metastases occasionally spread from the submucosa to neighboring structures. In spite of aggressive treatment, the prognosis was extremely poor because of multiple spread of carcinoma to local regions, lymph nodes, and distant organs. The clinicopathologic characteristics of this disease and possible treatment are discussed.
对35例发生胃转移的食管癌患者进行了分析。10例在手术标本中发现，25例在尸检时发现。所有患者均为男性，平均年龄62岁。原发灶最常见于胸段食管中部，且大于7cm。29%的患者为未分化癌。34%的患者可见原发灶向邻近结构的局部扩散。主要表现为淋巴浸润、食管壁内转移以及淋巴结转移。胃内转移灶大多位于贲门，大小小于2cm或大于4cm，类似黏膜下肿瘤。胃转移灶偶尔从黏膜下层扩散至邻近结构。尽管采取了积极治疗，但由于癌肿向局部区域、淋巴结和远处器官的多处扩散，预后极差。本文讨论了该疾病的临床病理特征及可能的治疗方法。
