Kelly J W, Sagebiel R W, Blois M S
Cancer. 1985 Nov 1;56(9):2287-91. doi: 10.1002/1097-0142(19851101)56:9<2287::aid-cncr2820560924>3.0.co;2-y.
A total of 844 cutaneous malignant melanomas were examined prospectively for the presence or absence of histologic regression within the primary tumor. Cases were then stratified into three groups according to tumor thickness and survival was compared between substrata with and without regression in each group. The distribution of other major prognostic variables within these substrata was assessed and their influence as potential confounding variables considered. No statistically significant effect of regression on survival was found in any of the three thickness strata. These results do not confirm the finding of an earlier study, which suggested that regression may be a poor prognostic sign when found in association with thin malignant melanomas. Regression was almost invariably associated with the radial growth phase of melanomas. Regression was more common in male than in female patients, and was more frequent in association with truncal than extremity or head and neck melanomas.
对总共844例皮肤恶性黑色素瘤进行前瞻性检查，以确定原发性肿瘤内是否存在组织学消退。然后根据肿瘤厚度将病例分为三组，并比较每组中有和没有消退的亚组之间的生存率。评估这些亚组中其他主要预后变量的分布，并考虑它们作为潜在混杂变量的影响。在三个厚度亚组中的任何一个中，均未发现消退对生存率有统计学上的显著影响。这些结果并未证实早期一项研究的发现，该研究表明，当与薄的恶性黑色素瘤相关联时，消退可能是一个不良的预后指标。消退几乎总是与黑色素瘤的放射状生长期相关。消退在男性患者中比在女性患者中更常见，并且与躯干黑色素瘤相关的频率高于与四肢或头颈部黑色素瘤相关的频率。
