Søndergaard K, Hou-Jensen K
Virchows Arch A Pathol Anat Histopathol. 1985;408(2-3):241-7. doi: 10.1007/BF00707986.
486 patients with primary cutaneous malignant melanoma clinical stage I were examined in order to evaluate the prognostic importance of partial regression in thin lesions. All the melanomas measured 1 mm or less in maximal thickness. The study showed that past regression with fibrotic scar tissue adversely affected survival in patients with thin melanomas. The 10 year survival was 95% for patients without regression in contrast to 79% for patients with past regression. It was, furthermore, demonstrated that active regression without fibrotic scar tissue did not influence survival significantly. The wider and the thicker the fibrotic area, the poorer the survival. Although the prognostic importance of this finding was not statistically significant, we suggest that the horizontal width of the fibrotic area in particular may be a valuable prognostic guide in thin melanomas with past regression.
对486例原发性皮肤恶性黑色素瘤临床I期患者进行了检查，以评估薄病灶中部分消退的预后重要性。所有黑色素瘤的最大厚度均为1毫米或更小。研究表明，伴有纤维化瘢痕组织的既往消退对薄黑色素瘤患者的生存有不利影响。无消退患者的10年生存率为95%，而有既往消退患者的10年生存率为79%。此外，还证明无纤维化瘢痕组织的活动性消退对生存无显著影响。纤维化区域越宽越厚，生存率越低。尽管这一发现的预后重要性在统计学上不显著，但我们认为，特别是纤维化区域的水平宽度可能是既往有消退的薄黑色素瘤的一个有价值的预后指标。
