Li X, Pang X, Mu C, Zhang F, Wang C, Zhang G
Tianjin Center for Tuberculosis Control, Tianjin 300011, China.
IJTLD Open. 2025 Jun 13;2(6):346-351. doi: 10.5588/ijtldopen.24.0684. eCollection 2025 Jun.
Individuals with mental illness are susceptible to TB. This study aimed to investigate a TB epidemic in a male psychiatric hospital to explore its potential for institutional spread.
From April 2022 to March 2023, 19 TB cases were diagnosed in a male psychiatric hospital. Epidemiological investigations and screening of close contacts were carried out.
A total of 400 psychiatric patients and 160 staff members were screened for TB. The overall positive rate was 37.15%, with 43.09% among patients and 22.93% among staff. Ultimately, a total of 17 psychiatric patients (including 2 index cases, 5 active cases, and 11 confirmed cases) and 2 staff (1 active case and 1 confirmed case) were diagnosed. The overall attack rate was 3.36%, with 4.20% in patients and 1.24% in staff. Whole-genome sequencing revealed that 3 drug-resistant patients from a third Department had mutations at two loci (rpoB and rpsL) with fewer than 6 SNPs.
Strengthening surveillance and conducting comprehensive epidemiological investigations for any occurrence of two or more TB cases is of utmost importance. Additionally, enhancing diagnostic capabilities and ensuring strict adherence to infection control protocols during patient care are essential measures to prevent TB outbreak.
患有精神疾病的个体易患结核病。本研究旨在调查一家男性精神病医院的结核病疫情，以探索其在机构内传播的可能性。
2022年4月至2023年3月，一家男性精神病医院诊断出19例结核病病例。开展了流行病学调查并对密切接触者进行了筛查。
共对400名精神科患者和160名工作人员进行了结核病筛查。总体阳性率为37.15%，患者中为43.09%，工作人员中为22.93%。最终，共诊断出17例精神科患者（包括2例索引病例、5例活动性病例和11例确诊病例）和2名工作人员（1例活动性病例和1例确诊病例）。总体发病率为3.36%，患者中为4.20%，工作人员中为1.24%。全基因组测序显示，来自第三个科室的3例耐药患者在两个位点（rpoB和rpsL）发生了突变，单核苷酸多态性少于6个。
加强监测并对任何两例或更多结核病病例的发生进行全面流行病学调查至关重要。此外，提高诊断能力并在患者护理期间确保严格遵守感染控制方案是预防结核病暴发的重要措施。
