Li Shu, Zou Yi, McMasters Austin, Chen Fuxiang, Yan Jun
Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville School of Medicine, Louisville, United States.
Department of Clinical Laboratory, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Elife. 2025 Jun 18;14:e104920. doi: 10.7554/eLife.104920.
In the past, immune memory was considered an exclusive feature of the adaptive immune system. However, accumulating evidence suggests that the innate immune system, the most primitive and fundamental component of immunity, can mount more robust responses to non-specific stimuli following prior exposure to different types of initial stimuli, a phenomenon known as trained immunity. Trained immunity has been extensively studied in diverse disease contexts, including infectious diseases, autoimmune disorders, and chronic inflammatory conditions. Notably, significant advancements have been made in recent years in understanding the roles and therapeutic potential of trained immunity in oncology. This review aims to explore the multifaceted roles of trained immunity across different cancer types, providing a comprehensive summary of the pertinent stimuli and associated molecular mechanisms. Additionally, we evaluate the clinical applications of various trained immunity stimuli in cancer therapy and offer perspectives on future directions for integrating trained immunity into cancer treatment strategies.
过去，免疫记忆被认为是适应性免疫系统的独特特征。然而，越来越多的证据表明，先天免疫系统作为免疫最原始和最基本的组成部分，在先前暴露于不同类型的初始刺激后，能够对非特异性刺激产生更强有力的反应，这一现象被称为训练免疫。训练免疫已在多种疾病背景下得到广泛研究，包括传染病、自身免疫性疾病和慢性炎症性疾病。值得注意的是，近年来在理解训练免疫在肿瘤学中的作用和治疗潜力方面取得了重大进展。本综述旨在探讨训练免疫在不同癌症类型中的多方面作用，全面总结相关刺激因素和相关分子机制。此外，我们评估了各种训练免疫刺激因素在癌症治疗中的临床应用，并对将训练免疫整合到癌症治疗策略中的未来方向提出了见解。
