Sugiyama H, Hatano T, Takayanagi K, Aoyama H, Goto T
Clin Ther. 1985;7(5):607-10.
The transfer of cefoperazone into exudates from excoriated skin wounds was studied in 13 adolescent and adult patients. Subjects were given an intravenous bolus injection of 50 mg/kg of body weight. Concentrations of cefoperazone in serum and in exudate fluids were determined by bioassay using Escherichia coli as the test organism. Mean (+/- SD) cefoperazone concentration in serum reached 333.3 +/- 103.3 micrograms/ml 30 minutes after the injection and decreased to 16.4 +/- 5.7 micrograms/ml eight hours after the injection. In exudate fluids, the peak value was 52.7 +/- 22.1 micrograms/ml at one hour. Eight hours after the injection, the mean concentration in the exudate was 10.7 +/- 7.2 micrograms/ml, which was considerably above the minimum inhibitory concentrations for important pathogens.
对13名青少年和成年患者进行了研究，以观察头孢哌酮从皮肤擦伤伤口进入渗出液的情况。受试者静脉推注50mg/kg体重的药物。采用大肠杆菌作为测试微生物，通过生物测定法测定血清和渗出液中头孢哌酮的浓度。注射后30分钟，血清中头孢哌酮的平均（±标准差）浓度达到333.3±103.3μg/ml，注射后8小时降至16.4±5.7μg/ml。在渗出液中，1小时时的峰值为52.7±22.1μg/ml。注射后8小时，渗出液中的平均浓度为10.7±7.2μg/ml，大大高于重要病原体的最低抑菌浓度。
