Muder R R, Yu V L, Johnson J, Thearle P, Lyon J, Diven W
Antimicrob Agents Chemother. 1984 Apr;25(4):473-5. doi: 10.1128/AAC.25.4.473.
Cefoperazone penetration into skeletal muscle and wound drainage in patients undergoing major surgery of the head and neck was measured by high-pressure liquid chromatography. Cefoperazone (2 g) was infused over 30 min before surgery and every 8 h for three postoperative doses. Simultaneous samples of serum and sternomastoid muscle were collected in 18 patients at 135 to 480 min after infusion. Mean cefoperazone concentrations in muscle tissue were 17.1% of those in simultaneously collected serum. Steady-state wound drainage concentrations after the fourth dose of cefoperazone averaged 55.2 micrograms/ml at 1 to 2 h and 62.1 micrograms/ml at 2 to 3 h. Simultaneous steady-state serum and wound fluid samples were obtained at regular intervals in six patients. In all patients, the peak level in wound fluid exceeded 25 micrograms/ml. Thus, cefoperazone reaches interstitial fluid concentration in soft tissue that exceeds the MICs required to inhibit the usual pathogens found at the site of wound infection after head and neck surgery.
采用高压液相色谱法测定了头孢哌酮在接受头颈大手术患者骨骼肌中的渗透情况及伤口引流液中的药物浓度。手术前30分钟静脉输注头孢哌酮（2g），术后每8小时给药一次，共给药3次。在输注后135至480分钟，采集了18例患者的血清和胸锁乳突肌同步样本。肌肉组织中头孢哌酮的平均浓度为同时采集血清中浓度的17.1%。头孢哌酮第四剂给药后，伤口引流液的稳态浓度在1至2小时平均为55.2微克/毫升，在2至3小时平均为62.1微克/毫升。对6例患者定期采集同步的稳态血清和伤口引流液样本。在所有患者中，伤口引流液中的峰值浓度均超过25微克/毫升。因此，头孢哌酮在软组织中的间质液浓度超过了抑制头颈手术后伤口感染部位常见病原体所需的最低抑菌浓度。
