Miranda Lívia Reis de, Luciano Eduardo de Paiva, Rizzo Eduarda Andrea Silva, Oliveira Marissol Fernandes, Cortelli Sheila Cavalca, Barbosa Walnei Fernandes
Universidade de Taubaté, Taubaté, SP, Brazil.
Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2025 Jun 16;23:eRC1377. doi: 10.31744/einstein_journal/2025RC1377. eCollection 2025.
Polymethylmethacrylate is a microsphere-based plastic used in aesthetic procedures. However, it can cause granuloma formation and severe hypercalcemia, often accompanied by renal impairment, which is a significant concern. Despite increasing reports, there is no standardized treatment approach for polymethylmethacrylate-induced hypercalcemia, and its incidence remains underreported. In this study, we present three cases of polymethylmethacrylate users who developed severe hypercalcemia that was resistant to conventional treatments, resulting in deteriorating renal function. These patients achieved symptom control with cinacalcet, a medication primarily used to treat secondary hyperparathyroidism, severe primary hyperparathyroidism, and parathyroid cancer.
聚甲基丙烯酸甲酯是一种用于美容手术的基于微球的塑料。然而，它可导致肉芽肿形成和严重高钙血症，常伴有肾功能损害，这是一个重大问题。尽管报告不断增加，但对于聚甲基丙烯酸甲酯所致高钙血症尚无标准化的治疗方法，其发病率仍报告不足。在本研究中，我们报告了3例使用聚甲基丙烯酸甲酯后发生严重高钙血症的患者，这些高钙血症对传统治疗耐药，导致肾功能恶化。这些患者使用西那卡塞实现了症状控制，西那卡塞是一种主要用于治疗继发性甲状旁腺功能亢进、严重原发性甲状旁腺功能亢进和甲状旁腺癌的药物。
