A cut-off value for nuchal translucency in the prediction of composite adverse outcome in cystic hygroma cases.

OBJECTIVE

The aim of this study was to determine a cut-off value for nuchal translucency in the prediction of composite adverse outcome in cystic hygroma cases.

METHODS

This study was designed retrospectively in the perinatology department of a tertiary hospital. All fetuses followed up with a diagnosis of cystic hygroma between 2019 and 2023 were included in the study. Demographic characteristics, prenatal ultrasound findings, non-invasive screening test results, invasive diagnostic test results, clinical management, and postnatal outcomes were evaluated. A total of 34 patients diagnosed with cystic hygroma by prenatal ultrasonography were included in the study. The 50th percentile nuchal translucency value of cystic hygroma cases was 5.2 mm. Cystic hygroma cases were divided into two groups as nuchal translucency <5.2 mm and ≥5.2 mm. A receiver operator characteristics analysis was performed to determine an optimal cut-off value of nuchal translucency in the prediction of composite adverse outcome.

RESULTS

There were no statistically significant differences between the groups for chromosomal/structural abnormalities and fetal losses. Chorionic villus sampling was performed in 28 patients, and amniocentesis was performed in one patient; five patients did not accept any invasive procedures. Nineteen cases had a chromosomal abnormality in chorionic villus sampling, while nine had a normal karyotype. The result of the amniocentesis was trisomy 18. A cut-off value of 4.03 mm was found for nuchal translucency in the prediction of composite adverse outcome (76.3% sensitivity, 66.7% specificity).

CONCLUSIONS

Composite adverse outcome seems to be more common in cystic hygroma cases with an nuchal translucency ≥4.03 mm.