松鼠猴对气管内接种甲型流感病毒/新泽西/76（猪）株的反应。
Reaction of squirrel monkeys to intratracheal inoculation with influenza/A/New Jersey/76 (swine) virus.
作者信息
Berendt R F, Hall W C
出版信息
Infect Immun. 1977 May;16(2):476-9. doi: 10.1128/iai.16.2.476-479.1977.
Abstract
To determine whether a model could be established for laboratory investigations, nine squirrel monkeys were inoculated intratracheally with 10(7) median egg-infectious doses of influenza virus type A/New Jersey/8/76 (HSW1N1) (swine influenza virus). They responded with clinically detectable illness including fever, leukopenia, decreased food consumption, increased respiratory rate, occasional coughing, labored breathing, nasal discharge, and lethargy. Convalescence was well advanced by the day 10. All monkeys excreted virus for 7 to 8 days. A scoring procedure (illness score) has been developed for use in studies of vaccine and chemotherapeutic efficacy.
摘要
为了确定是否能够建立用于实验室研究的模型，对9只松鼠猴经气管内接种10⁷个甲型流感病毒/新泽西/8/76（HSW1N1）（猪流感病毒）的半数鸡胚感染剂量。它们出现了临床上可检测到的疾病反应，包括发热、白细胞减少、食物摄入量减少、呼吸频率增加、偶尔咳嗽、呼吸困难、鼻分泌物增多和嗜睡。到第10天时恢复情况良好。所有猴子的病毒排泄期为7至8天。已开发出一种评分程序（疾病评分）用于疫苗和化疗疗效研究。
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