金刚烷胺、盐酸金刚乙胺和利巴韦林对小鼠和松鼠猴感染的猪流感病毒的活性。
Activity of amantadine, rimantadine, and ribavirin against swine influenza in mice and squirrel monkeys.
作者信息
Scott G H, Stephen E L, Berendt R F
出版信息
Antimicrob Agents Chemother. 1978 Feb;13(2):284-8. doi: 10.1128/AAC.13.2.284.
Abstract
Amantadine, rimantadine, and ribavirin given orally, either prophylactically or therapeutically, reduced mortality and increased the survival time of 3-week-old mice infected with the type A/New Jersey/8/76 (swine) strain of influenza virus. In addition, amantadine and rimantadine, administered therapeutically, increased the rate of virus clearance from lungs of infected mice. Administration of amantadine either before or after virus challenge ameliorated the illness in squirrel monkeys; when administered therapeutically, it appeared to eliminate virus shedding from infected monkeys within hours after therapy was initiated.
摘要
口服金刚烷胺、甲基金刚烷胺和利巴韦林，无论是预防性给药还是治疗性给药，都能降低感染A/新泽西/8/76（猪）型流感病毒的3周龄小鼠的死亡率，并延长其存活时间。此外，治疗性给予金刚烷胺和甲基金刚烷胺可提高感染小鼠肺部病毒清除率。在病毒攻击前或攻击后给予金刚烷胺可改善松鼠猴的病情；治疗性给药时，似乎在开始治疗后数小时内就能消除感染猴的病毒排泄。
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