Dehghani Mohammad, Kojuri Javad, Ahmadi Afsane, Zare Morteza, Bonyadian Atefe, Hejazi Najmeh
Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Cardiovascular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Health Popul Nutr. 2025 Jun 18;44(1):205. doi: 10.1186/s41043-025-00944-w.
Depression is a prevalent mental health disorder in patients with cardiovascular disease worldwide. The purpose of this observational study was to determine the association between nutrients intake, food insecurity, and diet quality with depression in patients with coronary artery diseases (CAD).
This cross-sectional study was conducted on 225 coronary artery patients. Nutrients intake, diet quality (by calculating Framingham Nutrition Risk Score (FNRS)), food insecurity and depression status of patients were obtained by using standard validated questionnaires. Relevant statistical analyses including logistic regression were used to analyze all data. P-value ≤ 0.05 was considered significant.
The multivariate-adjusted regression model showed that a higher intake of total fat (P = 0.02, OR = 1.031) increases the odds of depression. However, a higher intake of PUFA and Vitamin B12 was associated with its lower odds. (P = 0.005, OR = 0.87 and P = 0.005, OR = 0.73, respectively). It also indicated food insecurity was associated with depression in CAD patients (P < 0.001, OR = 6.92). FNRS could not show any significant association.
This study indicated that the dietary intake of PUFA and vitamin B12 were negatively associated with depression, while the intake of total fat from diet was directly associated with depression and might be considered as a risk factor in CAD patients. Furthermore, food insecurity was strongly and positively associated with depression in these patients. However, diet quality based on FNRS was not associated with depression among patients with CAD.
抑郁症是全球心血管疾病患者中普遍存在的心理健康障碍。这项观察性研究的目的是确定冠状动脉疾病(CAD)患者的营养摄入、粮食不安全状况和饮食质量与抑郁症之间的关联。
本横断面研究对225例冠状动脉疾病患者进行。通过使用标准的有效问卷获取患者的营养摄入、饮食质量(通过计算弗雷明汉营养风险评分(FNRS))、粮食不安全状况和抑郁状态。使用包括逻辑回归在内的相关统计分析方法对所有数据进行分析。P值≤0.05被认为具有统计学意义。
多变量调整回归模型显示,总脂肪摄入量较高(P = 0.02,OR = 1.031)会增加患抑郁症的几率。然而,多不饱和脂肪酸(PUFA)和维生素B12摄入量较高与患抑郁症的几率较低相关。(分别为P = 0.005,OR = 0.87和P = 0.005,OR = 0.73)。研究还表明,粮食不安全与CAD患者的抑郁症相关(P < 0.001,OR = 6.92)。FNRS未显示出任何显著关联。
本研究表明,饮食中PUFA和维生素B12的摄入量与抑郁症呈负相关,而饮食中总脂肪的摄入量与抑郁症直接相关,可能被视为CAD患者的一个风险因素。此外,粮食不安全与这些患者的抑郁症呈强烈正相关。然而,基于FNRS的饮食质量与CAD患者的抑郁症无关。