儿童长期禁食期间与燃料代谢相关的血液成分浓度。

The concentration of blood components related to fuel metabolism during prolonged fasting in children.

作者信息

Lamers K J, Doesburg W H, Gabreëls F J, Lemmens W A, Romsom A C, Wevers R A, Renier W O

出版信息

Clin Chim Acta. 1985 Oct 31;152(1-2):155-63. doi: 10.1016/0009-8981(85)90186-x.

Abstract

In order to study the relationship between sex, age and glucose, and the concentrations of various fuel related blood substrates in children during prolonged fasting, we have selected data of fasting procedures in 13 control children aged 3-5 yr, fasted 24 h, and 58 control children aged 6-15 yr, fasted 40 h. Compared to the blood results after overnight fast, glucose is decreased, and lactate, pyruvate, ketones and non-esterified fatty acids (NEFA's) are all clearly increased at the end of fast. The concentrations of alanine and triglycerides remain unchanged. The relation with sex, age and glucose has only been analyzed in the older children group. A sex-dependency is indicated for the ketones. Ketones are negatively related with age. NEFA's pyruvate and alanine are not age-related, whereas glucose, lactate and triglycerides are moderately age-dependent. Ketones are negatively related with glucose, whereas pyruvate, NEFA's and triglycerides are not glucose-related. Lactate and alanine are weakly related to glucose. The data demonstrate diminished glucose homeostasis and increased ketogenesis in younger children compared to older ones during prolonged fasting.

摘要

为了研究长期禁食期间儿童的性别、年龄与葡萄糖以及各种与燃料相关的血液底物浓度之间的关系，我们选取了13名3 - 5岁对照儿童禁食24小时以及58名6 - 15岁对照儿童禁食40小时的禁食程序数据。与过夜禁食后的血液结果相比，禁食结束时葡萄糖降低，乳酸、丙酮酸、酮体和非酯化脂肪酸（NEFA）均明显升高。丙氨酸和甘油三酯的浓度保持不变。仅在较大儿童组中分析了与性别、年龄和葡萄糖的关系。酮体存在性别依赖性。酮体与年龄呈负相关。NEFA、丙酮酸和丙氨酸与年龄无关，而葡萄糖、乳酸和甘油三酯有一定程度的年龄依赖性。酮体与葡萄糖呈负相关，而丙酮酸、NEFA和甘油三酯与葡萄糖无关。乳酸和丙氨酸与葡萄糖呈弱相关。数据表明，与年龄较大的儿童相比，年龄较小的儿童在长期禁食期间葡萄糖稳态降低，酮体生成增加。