Mahmutovic Mirsad, Shrestha Manisha, Ramos-Llordén Gabriel, Sung Dongsuk, Edwards Luke J, Chu Ying, Dubovan Paul I, Müller Alina, Hansen Sam-Luca J D, Ghotra Anpreet, Pine Kerrin J, Müller Roland, Weiskopf Nikolaus, Wald Lawrence L, Mekkaoui Choukri, Möller Harald E, Huang Susie Y, Keil Boris
Institute of Medical Physics and Radiation Protection, TH-Mittelhessen University of Applied Sciences, Giessen, Hesse, Germany.
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Magn Reson Med. 2025 Nov;94(5):2286-2303. doi: 10.1002/mrm.30606. Epub 2025 Jun 18.
To develop and test two high-density MRI coil arrays with integrated field monitoring systems for enhanced diffusion imaging with strong diffusion-sensitizing gradients.
Two multichannel head coils were constructed for first- and second-generation 3T Connectome MRI scanners, incorporating 64 and 72 receive channels, respectively. The array coils were evaluated using RF bench-level metrics, including quality factor, tuning, matching, and coupling measurements. Imaging performance was comprehensively assessed through metrics such as SNR, efficiency, and inter-channel noise correlations, and compared with and without field camera integration. Parallel imaging capability was evaluated using geometry (g)-factors. The field camera performance was characterized by quantifying phase errors and field probe FID lifetimes. In vivo DWI acquisitions with high -values were performed to evaluate the system's ability to correct higher-order field perturbations.
The developed arrays demonstrated up to 1.4-fold higher SNR and superior g-factor performance when compared to a commercially available 32-channel head coil. Integration of the field camera was achieved without compromising the performance of either system. In vivo imaging with concurrent field monitoring enabled accurate spatiotemporal field corrections, significantly reducing geometric distortions, blurring, and ghosting in high -value DWI.
The integration of high-density MRI arrays with field monitoring systems facilitated the capture and correction of spatiotemporal field perturbations during strong gradient activity, substantially enhancing image quality and diffusion parameter mapping quality. These advancements provide a robust platform for exploring the structural intricacies of the human connectome.
开发并测试两款集成了场监测系统的高密度MRI线圈阵列，用于在强扩散敏感梯度下增强扩散成像。
为第一代和第二代3T Connectome MRI扫描仪构建了两款多通道头部线圈，分别包含64个和72个接收通道。使用射频台架级指标对阵列线圈进行评估，包括品质因数、调谐、匹配和耦合测量。通过诸如信噪比、效率和通道间噪声相关性等指标全面评估成像性能，并比较有无场相机集成的情况。使用几何（g）因子评估并行成像能力。通过量化相位误差和场探头FID寿命来表征场相机性能。进行了具有高 值的体内DWI采集，以评估系统校正高阶场扰动的能力。
与市售的32通道头部线圈相比，所开发的阵列显示出高达1.4倍的更高信噪比和优异的g因子性能。场相机的集成并未损害任何一个系统的性能。同时进行场监测的体内成像实现了精确的时空场校正，显著减少了高 值DWI中的几何畸变、模糊和鬼影。
高密度MRI阵列与场监测系统的集成有助于在强梯度活动期间捕获和校正时空场扰动，大幅提高图像质量和扩散参数映射质量。这些进展为探索人类连接组的结构复杂性提供了一个强大的平台。
