Liu Houhe, Deng Yi, Li Jiayan, Lin Wen, Liu Chongzhi, Yang Xiaofei, Zhou Zunzhen, Jiang Yuan
College of Medicine, Linyi University, Linyi, Shandong, China.
Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Front Bioeng Biotechnol. 2025 Jun 4;13:1569889. doi: 10.3389/fbioe.2025.1569889. eCollection 2025.
In recent years, the research on plant-derived exosome-like nanoparticles (PELNs) has attracted increasing attention. Among these, ginger-derived exosome-like nanoparticles (GELNs) stand out due to their specific pharmacological activity and their role as reliable carriers for delivering both hydrophilic and hydrophobic drugs, as well as small RNAs, making them a noteworthy representative of plant-based natural nanostructured drug delivery systems (DDS). In this review, we first introduce the characteristics and engineering methods of GELN-based DDS to brush up on our current understanding and then focus on research progress to summarize their therapeutic application scope and challenges.
近年来，对植物源外泌体样纳米颗粒（PELNs）的研究越来越受到关注。其中，生姜源外泌体样纳米颗粒（GELNs）因其特定的药理活性以及作为递送亲水性和疏水性药物以及小RNA的可靠载体的作用而脱颖而出，使其成为基于植物的天然纳米结构药物递送系统（DDS）的一个值得注意的代表。在这篇综述中，我们首先介绍基于GELN的DDS的特性和工程方法，以梳理我们目前的认识，然后重点关注研究进展，总结其治疗应用范围和挑战。
