Deng Lizhen, Zhang Chunyuan, Tan Meiyun, Zeng Wei, Luo Guozhan, Li Ping
Department of Anesthesiology, Affiliated Boai Hospital of Zhongshan, Zhongshan, Guangdong, People's Republic of China.
J Pain Res. 2025 Jun 14;18:2983-2992. doi: 10.2147/JPR.S496223. eCollection 2025.
A new Chinese-developed intravenous anesthetic called ciprofol enhances propofol's effectiveness against GABAA receptors by adding cyclopropyl. This study aims to determine the optimal dosage of ciprofol for inducing general anesthesia in adult patients of different ages and its correlation with Narcotrend index (NTI).
105 patients were stratified into three age groups: 18-40 (Group A), 41-65 (Group B), and 66-85 (Group C) years. Initial doses of 0.4 mg/kg (Groups A and B) and 0.3 mg/kg (Group C) ciprofol tosilate were administered, adjusted by 0.05 mg/kg based on sedation efficacy. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale and Dixon up-and-down method were used to calculate ED50, ED95, and NTI50.
Effective dosages were: youth (ED50=0.526 mg/kg, ED95=0.610 mg/kg), middle-aged (ED50=0.366 mg/kg, ED95=0.450 mg/kg), and elderly (ED50=0.324 mg/kg, ED95=0.408 mg/kg). NTI50 were 38.068 (33.496-44.188), 44.963 (39.311-52.270), and 47.214 (39.792-57.420) for the three groups, respectively.
Ciprofol is safe and effective for anesthesia induction across age groups, with lower doses required for elderly patients. NTI reduction was dose-dependent and slower in elderly patients.
一种新的由中国研发的静脉麻醉剂环泊酚，通过添加环丙基增强了丙泊酚对γ-氨基丁酸A型（GABAA）受体的作用效果。本研究旨在确定环泊酚用于不同年龄成年患者全身麻醉诱导的最佳剂量及其与脑电双频指数（NTI）的相关性。
105例患者被分为三个年龄组：18至40岁（A组）、41至65岁（B组）和66至85岁（C组）。给予A组和B组初始剂量为0.4mg/kg、C组为0.3mg/kg的环泊酚对甲苯磺酸盐，根据镇静效果以0.05mg/kg进行调整。采用改良的警觉/镇静状态评估（MOAA/S）量表和序贯法计算半数有效剂量（ED50）、95%有效剂量（ED95）和半数NTI（NTI50）。
有效剂量分别为：青年组（ED50 = 0.526mg/kg，ED95 = 0.610mg/kg）、中年组（ED50 = 0.366mg/kg，ED95 = 0.450mg/kg）和老年组（ED50 = 0.324mg/kg，ED95 = 0.408mg/kg）。三组的NTI50分别为38.068（33.496 - 44.188）、44.963（39.311 - 52.270）和47.214（39.792 - 57.420）。
环泊酚用于各年龄组麻醉诱导均安全有效，老年患者所需剂量较低。老年患者NTI降低呈剂量依赖性且较为缓慢。
