Li Jie, Pan Xinyan, Bi Yanting, Huang Jian, Peng Jun, Bai ChunLing, Hou Jianhong, Chen Yang
Academy of Biomedical Engineering, Kunming Medical University, Kunming, China.
Department of Pathology, The First People's Hospital of Yunnan Province, Kunming, China.
Front Med (Lausanne). 2025 Jun 4;12:1556840. doi: 10.3389/fmed.2025.1556840. eCollection 2025.
The Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC).
Multi-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data, and cell-line drug sensitivity from TCGA and CCLE are delved into TDP characteristics.
Our thorough analysis reveals that patients with smaller span sizes TDP have a more intricate genome, moderate pathology, enhanced therapeutic response, favorable prognosis, a more active immune system, and higher drug sensitivity. In contrast, those with larger span sizes TDP exhibited opposite trends.
The integrated analysis underscores that an in-depth molecular assessment of TDP can offer invaluable insights into its role in cancers. Classification strategy of TDP could recognize the chemotherapy sensitivity of different NSCLC patients.
串联复制子表型（TDP）是一种在非小细胞肺癌（NSCLC）中普遍存在的重要基因组指标。
对来自TCGA和CCLE的多组学样本进行深入研究，包括DNA拷贝数、转录组学、体细胞单核苷酸变异、临床数据以及细胞系药物敏感性，以探究TDP特征。
我们的全面分析表明，TDP跨度较小的患者具有更复杂的基因组、中等程度的病理学特征、增强的治疗反应、良好的预后、更活跃的免疫系统以及更高的药物敏感性。相比之下，TDP跨度较大的患者则呈现相反的趋势。
综合分析强调，对TDP进行深入的分子评估可以为其在癌症中的作用提供宝贵的见解。TDP的分类策略可以识别不同NSCLC患者的化疗敏感性。
