Polman C H, Koetsier J C, Wolters E C
Clin Neurol Neurosurg. 1985;87(3):187-92. doi: 10.1016/0303-8467(85)90005-8.
In a retrospective study of 100 multiple sclerosis patients we compared the diagnostic classification according to the Schumacher/Rose criteria and the newest criteria, proposed by Poser et al. It is clear that by incorporating the results of laboratory investigations in the diagnostic criteria a firm diagnosis of multiple sclerosis can be reached more often and at an earlier stage of the disease. Evaluating abnormal laboratory findings, we found that it was possible to detect more than 90% of diagnostically important findings, i.e. findings effecting a change in diagnostic classification (from possible multiple sclerosis to probable or definite, from probable to definite), using only two of the laboratory tests: cerebrospinal fluid analysis and visual evoked response. Because the results of laboratory tests contributing to diagnostic classification are not specific for multiple sclerosis, the importance of evaluating the complete differential diagnosis of diseases that can be confused with multiple sclerosis is stressed.
在一项对100例多发性硬化症患者的回顾性研究中，我们根据舒马赫/罗斯标准以及波泽等人提出的最新标准对诊断分类进行了比较。显然，通过将实验室检查结果纳入诊断标准，能够更频繁地在疾病的早期阶段做出多发性硬化症的确切诊断。在评估异常实验室检查结果时，我们发现仅使用两项实验室检查，即脑脊液分析和视觉诱发电位，就能够检测出90%以上具有诊断重要性的结果，也就是那些会导致诊断分类改变的结果（从可能的多发性硬化症变为很可能或肯定的，从很可能变为肯定的）。由于有助于诊断分类的实验室检查结果并非多发性硬化症所特有，因此强调了评估可能与多发性硬化症混淆的疾病的完整鉴别诊断的重要性。
