Zhao Mengpo, Chen Jing, Luo Shengjun, Zhang Pian, Chen Jinliang, Sun Chenglong, Ren Zhaowen, Huang Yanju, Zhang Xiaoxiao, Xiang Hua, Huang Yuan, Wang Gang, Yuan Zi-Guo, Wang Xiaohu
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Livestock Disease Prevention, Guangdong Provincial Observation and Research Station for Animal Disease, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Front Vet Sci. 2025 Jun 4;12:1581043. doi: 10.3389/fvets.2025.1581043. eCollection 2025.
Pseudorabies (PR) is an important zoonotic viral disease that infects a wide range of animals, including humans. In recent years, the prevalence of pseudorabies virus (PRV) has caused great economic losses to the Chinese pig industry.
In this study, 40,050 serum samples were collected from 348 pig farms in 18 districts of Guangdong Province, China, between 2017 and 2022 to investigate the seroprevalence of wild-type PRV in pigs.
The results of the enzyme-linked immunosorbent assay (ELISA) showed that seropositivity for PRV gE antibodies was 25.28% (95% CI, 24.86% to 25.71%) at the pig level. However, the seropositivity of PRV gE antibodies reached 67.44 % (95% CI, 62.14% to 71.96%) at the farm level. To identify potential factors associated with the positive rate of PRV gE antibodies, logistic regression analysis was performed, and the results showed that the seropositivity rate of PRV gE was related to factors such as geographic distribution and season. To find areas with higher PR prevalence in Guangdong Province, China, we analyzed the data using SaTScan 10.2.5 software and identified five spatiotemporal clusters of higher PRV gE antibody positivity in Guangdong Province, China, with the highest prevalence from April to June 2018.
Our study revealed seroprevalence, associated influencing factors, and spatiotemporal clustering characteristics of PRV gE antibody positivity in Guangdong Province, China, in recent years. This provides new scientific data for the development of policies related to the prevention and control of wild-type pseudorabies epidemics in Guangdong Province, China.
伪狂犬病（PR）是一种重要的人畜共患病毒性疾病，可感染包括人类在内的多种动物。近年来，伪狂犬病病毒（PRV）的流行给中国养猪业造成了巨大经济损失。
本研究于2017年至2022年期间，从中国广东省18个地区的348个猪场收集了40050份血清样本，以调查猪群中野生型PRV的血清流行率。
酶联免疫吸附测定（ELISA）结果显示，在猪个体水平上，PRV gE抗体血清阳性率为25.28%（95%置信区间，24.86%至25.71%）。然而，在猪场水平上，PRV gE抗体血清阳性率达到67.44%（95%置信区间，62.14%至71.96%）。为了确定与PRV gE抗体阳性率相关的潜在因素，进行了逻辑回归分析，结果表明PRV gE血清阳性率与地理分布和季节等因素有关。为了找出中国广东省伪狂犬病流行率较高的地区，我们使用SaTScan 10.2.5软件对数据进行分析，确定了中国广东省五个PRV gE抗体阳性率较高的时空聚集区，其中2018年4月至6月的流行率最高。
我们的研究揭示了近年来中国广东省PRV gE抗体阳性的血清流行率、相关影响因素及时空聚集特征。这为中国广东省制定野生型伪狂犬病疫情防控相关政策提供了新的科学数据。
