Kavga Maria, Rudolf Jobst, Mitsa Foteini, Raikos Nikolaos, Fotoulaki Maria, Panagopoulou Paraskevi
4th Department of Pediatrics, Medical School (MK,MF,PP), Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
Department of Neurology (JR), Papageorgiou General Hospital, Thessaloniki, Greece.
J Pediatr Pharmacol Ther. 2025 Jun;30(3):381-383. doi: 10.5863/JPPT-24-00076. Epub 2025 Jun 9.
Eslicarbazepine acetate has been recently licensed as an anti-epileptic medication to be used in adolescents. Data regarding dosing and overdosing are still limited in the literature. We describe a rare case of intentional eslicarbazepine overdosing in a previously healthy teenager who presented with neurological toxicity. Management of hyperhydration with diuretics, haloperidol, and midazolam proved to be helpful both in inducing rapid clearance through the kidneys and in managing symptoms of agitation, respectively.
醋酸艾司利卡西平最近已被批准作为一种抗癫痫药物用于青少年。关于给药和过量用药的数据在文献中仍然有限。我们描述了一例罕见的故意过量服用醋酸艾司利卡西平的病例,患者为一名此前健康的青少年,出现了神经毒性。事实证明,使用利尿剂、氟哌啶醇和咪达唑仑进行补液治疗,分别有助于通过肾脏快速清除药物以及控制激动症状。